肝纖維化無創性診斷的研究進展_《華西醫學》

作者：

盧利霞 , 楊碧偉 ,  王麗春

四川大學華西醫院生物治療國家重點實驗室感染性疾病研究室（成都，610041）;

關鍵詞：

肝纖維化無創性診斷 FibroScan聯合

DOI：

10.7507/1002-0179.20130048

視頻：

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肝纖維化是慢性肝病的重要病理階段，也是進一步向肝硬化發展的主要中間環節，目前的研究認為肝纖維化是可逆的，而肝硬化是不可逆的。因此肝纖維化的早期診斷和及時干預對于疾病的進展及預后的改善極為重要。近年來肝纖維化的診斷手段與技術方面得到了很大的發展，尤其是無創性診斷方法。現對肝纖維化無創性診斷的研究進展作一綜述。

引用本文： 盧利霞,楊碧偉,王麗春. 肝纖維化無創性診斷的研究進展. 華西醫學, 2013, 28(1): 148-151. doi: 10.7507/1002-0179.20130048 復制

1.	Han KN, Yoon KT. Mew diagnostic method for liver fibrosis and cirrhosis[J]. Intervirology, 2008, 51(1): 11-16.
2.	Patel K. Noninvasive tools to assess liver disease[J]. Curr Opin Gastroenterol, 2010, 26(3): 227-233.
3.	Wong GL, Wong VW, Choi, et al. Development of a noninvasive algorithm with transient elastography(FibroScan)and serum test formula for advanced liver fibrosis in chronic hepatitis B[J]. Aliment Pharm Ther, 2010, 31(10): 1095-1103.
4.	Cadranel JF, Rufat P, Degos F. Practices of liver biopsy in France:results of a prospective nationwide survey[J]. Hepatology, 2000, 32(3): 477-481.
5.	Sebastiani G. Non-invasive assessment of liver fibrosis in chronic liver diseases: implementation in clinical practice and decisional[J]. World J Gastroenterol, 2009, 15(18): 2190-2203.
6.	王軍, 趙權, 路穎, 等. 血清層粘連蛋白水平檢測對肝病患者肝纖維化的診斷意義[J]. 實用醫藥雜志, 2011, 28(2): 106-107.
7.	姜菲菲, 王文靜, 趙秀英, 等. 國產化學發光試劑檢測4項血清肝纖維化標志物對肝纖維化診斷的應用分析[J]. 北京醫學, 2012, 34(3): 164-168.
8.	趙治鳳, 賈秋龍. 肝纖維化四項聯合檢測對410例慢性肝炎診斷的臨床意義[J]. 中國民康醫學, 2012, 24(7): 798-799.
9.	Jarcuska P, Janicko M, Veseliny E, et al. Circulating markers of liver fibrosis progression[J]. Clin Chim Acta, 2010, 411(15-16): 1009-1017.
10.	李麗, 展玉濤. 肝纖維化無創性診斷研究進展[J]. 實用肝臟病雜志, 2010, 13(2): 145-147.
11.	Myers RP, Tainturier MH, Ratziu V, et al. Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B[J]. Hepatology, 2003, 39(2): 222-230.
12.	Anais VP, Vincent M, Bertrand N, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and Fibro Test[J]. Hepatology, 2007, 46(1): 33-36.
13.	張彥亮, 洪定玲, 邊維良, 等. FIB-4指數對慢性乙型肝炎患者肝纖維化的診斷價值[J]. 胃腸病學和肝病學雜志, 2009, 18(3): 213-214.
14.	張文勝, 王寶恩, 王泰領, 等. 慢性乙型肝炎肝纖維化無創性診斷模型的建立[J]. 中華肝臟病雜志, 2006, 14(3): 169-173.
15.	Li WX, Zhao XT, Wm C, et al. Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography[J]. J Digest Dis, 2010, 11(4): 215-223.
16.	Wang Y, Ganger DR, Levitsky J, et al. Assessment of chronic hepatitis and fibrosis: comparison of Mr elastography and diffusion-weighted imaging[J]. Am J Roentgenol, 2011, 196(3): 553-561.
17.	朱霞, 唐紅. 瞬時彈性掃描儀在肝纖維化診斷中的應用價值[J]. 世界華人消化雜志, 2010, 18(9): 906-912.
18.	Jung MK, Cho HJ, Lee HC, et al. Comparison of transient elastography and hepatic fibrosis assessed by histology in chronic liver disease[J]. Korean J Gastroenterol, 2008, 51(4): 241-247.
19.	Sandrin L, Fourquet B, Hasquenoph JM, et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis[J]. Ultrasound Med Biol, 2003, 29(12): 1705-1713.
20.	Coco B, Oliveri F, Maina AM, et al. Transient elastography:a new surrogate marker of liver fibrosis influenced by major changes of transaminases[J]. J Viral Hepat, 2007, 14(5): 360-369.
21.	Kim SU, Han KH, Park IY, et al. Liver stiffness measurement using FibroScan is influenced by serum total bilirubin in acute hepatitis[J]. Liver Int, 2009, 29(6): 810-815.
22.	Millonig G, Reimann FM, Friedrich S, et al. Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis[J]. Hepatology, 2008, 48(5): 1718-1723.
23.	Scott DR, Levy MT. Liver transient elastography (Fibroscan): a place in the management algorithms of chronic viral hepatitis[J]. Antivir Ther, 2010, 15(1): 1-11.
24.	楊愛婷, 白艷鋒, 尤紅. Fibroscan對乙型肝炎肝纖維化診斷的研究進展[J]. 實用肝臟病雜志, 2009, 12(2): 142-144.
25.	Alisi A, Pinzani M, Nobili V. Diagnostic power of FibroScan in predicting liver fibrosis in nonalcoholic fatty liver disease[J]. Hepatology, 2009, 50(6): 2048-2049.
26.	薛芳, 施裕新, 李桂明, 等. 瞬時彈性成像對肝纖維化的診斷價值[J]. 中國臨床醫學, 2012, 19(1): 77-79.
27.	Fraquelli M, Rigamonti C, Casazza G, et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease[J]. Gut, 2007, 56(7): 968-973.
28.	Salles N, Dussarat P, Foucher J, et al. Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients[J]. Gastroenterol Clin Biol, 2009, 33(2): 126-132.
29.	Roulot D, Czernichow S, Le CH, et al. Liver stiffness values in apparently healthy subjects: influence of gender and metabolic syndrome[J]. J Hepatol, 2008, 48(4): 606-613.
30.	Chang PE, Lui HF, Chau YP, et al. Prospective evaluation of transient elastography for the diagnosis of hepatic fibrosis in Asians: comparison with liver biopsy and aspartate transaminase platelet ratio index[J]. Aliment Pharm Therap, 2008, 28(1): 51-56.
31.	Castera L, Vergniol J, Foucher J, et al. Prospective comparison of transient elastography, fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C[J]. Gastroenterology, 2005, 128(2): 343-350.
32.	Fraquelli M, Rigamonti C, Casazza G, et al. A sequential predictive algorithm combining APRI and transient elastography (TE) for diagnosing liver fibrosis in chronic hepatitis C[J]. Hepatology, 2008, 48(Suppl 4): 1195A.
33.	紀冬, 邵清, 韓萍, 等. 瞬時彈性成像聯合血清學標志物檢測對肝纖維化的診斷療效分析[J]. 解放軍醫學雜志, 2011, 36(11): 1136-1138.
34.	李繼昌, 頓國亮. 肝纖維化診斷中肝穿病理分期及非創傷性指標相關性研究[J]. 中國現代醫生, 2010, 48(12): 33.
35.	林滬, 陳黎明, 葉文華, 等. 肝纖維化無創性診斷技術應用的新進展[J]. 傳染病信息, 2010, 23(3): 187-190.

1. 　Han KN, Yoon KT. Mew diagnostic method for liver fibrosis and cirrhosis[J]. Intervirology, 2008, 51(1): 11-16.
2. 　Patel K. Noninvasive tools to assess liver disease[J]. Curr Opin Gastroenterol, 2010, 26(3): 227-233.
3. 　Wong GL, Wong VW, Choi, et al. Development of a noninvasive algorithm with transient elastography(FibroScan)and serum test formula for advanced liver fibrosis in chronic hepatitis B[J]. Aliment Pharm Ther, 2010, 31(10): 1095-1103.
4. 　Cadranel JF, Rufat P, Degos F. Practices of liver biopsy in France:results of a prospective nationwide survey[J]. Hepatology, 2000, 32(3): 477-481.
5. 　Sebastiani G. Non-invasive assessment of liver fibrosis in chronic liver diseases: implementation in clinical practice and decisional[J]. World J Gastroenterol, 2009, 15(18): 2190-2203.
6. 　王軍, 趙權, 路穎, 等. 血清層粘連蛋白水平檢測對肝病患者肝纖維化的診斷意義[J]. 實用醫藥雜志, 2011, 28(2): 106-107.
7. 　姜菲菲, 王文靜, 趙秀英, 等. 國產化學發光試劑檢測4項血清肝纖維化標志物對肝纖維化診斷的應用分析[J]. 北京醫學, 2012, 34(3): 164-168.
8. 　趙治鳳, 賈秋龍. 肝纖維化四項聯合檢測對410例慢性肝炎診斷的臨床意義[J]. 中國民康醫學, 2012, 24(7): 798-799.
9. 　Jarcuska P, Janicko M, Veseliny E, et al. Circulating markers of liver fibrosis progression[J]. Clin Chim Acta, 2010, 411(15-16): 1009-1017.
10. 　李麗, 展玉濤. 肝纖維化無創性診斷研究進展[J]. 實用肝臟病雜志, 2010, 13(2): 145-147.
11. 　Myers RP, Tainturier MH, Ratziu V, et al. Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B[J]. Hepatology, 2003, 39(2): 222-230.
12. 　Anais VP, Vincent M, Bertrand N, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and Fibro Test[J]. Hepatology, 2007, 46(1): 33-36.
13. 　張彥亮, 洪定玲, 邊維良, 等. FIB-4指數對慢性乙型肝炎患者肝纖維化的診斷價值[J]. 胃腸病學和肝病學雜志, 2009, 18(3): 213-214.
14. 　張文勝, 王寶恩, 王泰領, 等. 慢性乙型肝炎肝纖維化無創性診斷模型的建立[J]. 中華肝臟病雜志, 2006, 14(3): 169-173.
15. 　Li WX, Zhao XT, Wm C, et al. Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography[J]. J Digest Dis, 2010, 11(4): 215-223.
16. 　Wang Y, Ganger DR, Levitsky J, et al. Assessment of chronic hepatitis and fibrosis: comparison of Mr elastography and diffusion-weighted imaging[J]. Am J Roentgenol, 2011, 196(3): 553-561.
17. 　朱霞, 唐紅. 瞬時彈性掃描儀在肝纖維化診斷中的應用價值[J]. 世界華人消化雜志, 2010, 18(9): 906-912.
18. 　Jung MK, Cho HJ, Lee HC, et al. Comparison of transient elastography and hepatic fibrosis assessed by histology in chronic liver disease[J]. Korean J Gastroenterol, 2008, 51(4): 241-247.
19. 　Sandrin L, Fourquet B, Hasquenoph JM, et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis[J]. Ultrasound Med Biol, 2003, 29(12): 1705-1713.
20. 　Coco B, Oliveri F, Maina AM, et al. Transient elastography:a new surrogate marker of liver fibrosis influenced by major changes of transaminases[J]. J Viral Hepat, 2007, 14(5): 360-369.
21. 　Kim SU, Han KH, Park IY, et al. Liver stiffness measurement using FibroScan is influenced by serum total bilirubin in acute hepatitis[J]. Liver Int, 2009, 29(6): 810-815.
22. 　Millonig G, Reimann FM, Friedrich S, et al. Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis[J]. Hepatology, 2008, 48(5): 1718-1723.
23. 　Scott DR, Levy MT. Liver transient elastography (Fibroscan): a place in the management algorithms of chronic viral hepatitis[J]. Antivir Ther, 2010, 15(1): 1-11.
24. 　楊愛婷, 白艷鋒, 尤紅. Fibroscan對乙型肝炎肝纖維化診斷的研究進展[J]. 實用肝臟病雜志, 2009, 12(2): 142-144.
25. 　Alisi A, Pinzani M, Nobili V. Diagnostic power of FibroScan in predicting liver fibrosis in nonalcoholic fatty liver disease[J]. Hepatology, 2009, 50(6): 2048-2049.
26. 　薛芳, 施裕新, 李桂明, 等. 瞬時彈性成像對肝纖維化的診斷價值[J]. 中國臨床醫學, 2012, 19(1): 77-79.
27. 　Fraquelli M, Rigamonti C, Casazza G, et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease[J]. Gut, 2007, 56(7): 968-973.
28. 　Salles N, Dussarat P, Foucher J, et al. Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients[J]. Gastroenterol Clin Biol, 2009, 33(2): 126-132.
29. 　Roulot D, Czernichow S, Le CH, et al. Liver stiffness values in apparently healthy subjects: influence of gender and metabolic syndrome[J]. J Hepatol, 2008, 48(4): 606-613.
30. 　Chang PE, Lui HF, Chau YP, et al. Prospective evaluation of transient elastography for the diagnosis of hepatic fibrosis in Asians: comparison with liver biopsy and aspartate transaminase platelet ratio index[J]. Aliment Pharm Therap, 2008, 28(1): 51-56.
31. 　Castera L, Vergniol J, Foucher J, et al. Prospective comparison of transient elastography, fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C[J]. Gastroenterology, 2005, 128(2): 343-350.
32. 　Fraquelli M, Rigamonti C, Casazza G, et al. A sequential predictive algorithm combining APRI and transient elastography (TE) for diagnosing liver fibrosis in chronic hepatitis C[J]. Hepatology, 2008, 48(Suppl 4): 1195A.
33. 　紀冬, 邵清, 韓萍, 等. 瞬時彈性成像聯合血清學標志物檢測對肝纖維化的診斷療效分析[J]. 解放軍醫學雜志, 2011, 36(11): 1136-1138.
34. 　李繼昌, 頓國亮. 肝纖維化診斷中肝穿病理分期及非創傷性指標相關性研究[J]. 中國現代醫生, 2010, 48(12): 33.
35. 　林滬, 陳黎明, 葉文華, 等. 肝纖維化無創性診斷技術應用的新進展[J]. 傳染病信息, 2010, 23(3): 187-190.

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肝纖維化無創性診斷的研究進展

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