硬化性上皮樣纖維肉瘤臨床病理分析_《華西醫學》

作者：

陳仕高 , 梅傲男 , 徐秀英 ,  葉綠

高新達安醫學檢驗所病理實驗室（成都，611731）;

關鍵詞：

軟組織腫瘤纖維肉瘤硬化性上皮樣纖維肉瘤免疫組織化學

DOI：

10.7507/1002-0179.20130379

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目的　探討硬化性上皮樣纖維肉瘤（SEF）的臨床病理學特征。方法　對2012年3月收治的l例SEF患者進行組織學觀察、免疫組織化學檢查并復習相關文獻。結果　SEF主要以細胞質透亮的上皮樣腫瘤細胞伴大量透明變性膠原纖維為特征，瘤細胞排列主要呈條索狀、巢狀。腫瘤細胞波形蛋白陽性表達，細胞角蛋白和平滑肌肌動蛋白陰性表達。結論　SEF是一種較為罕見的軟組織腫瘤，應注意與一些具有上皮樣形態和硬化性間質的腫瘤相鑒別。

引用本文： 陳仕高,梅傲男,徐秀英,葉綠. 硬化性上皮樣纖維肉瘤臨床病理分析. 華西醫學, 2013, 28(8): 1215-1217. doi: 10.7507/1002-0179.20130379 復制

1.	Meis-Kindblom JM, Kindblom LG, Enzinger FM. Sclerosing epithelioid fibrosarcoma: a variant of fibrosarcoma simulating carcinoma[J]. Am J Surg Pathol, 1995, 19(9): 979-993.
2.	Folk GS, Williams SB, Foss RB, et al. Oral and maxillofacial sclerosing epithelioid fibroscarcoma: report of five cases[J]. Head Neck Pathol, 2007, 1(1): 13-20.
3.	Ossendorf C, Studer GM, Bode B, et al. Sclerosing epithelioid fibrosarcoma: case presentation and a systematic review[J]. Clin Orthop Relat Res, 2008, 466(6): 1485-1491.
4.	Tomimaru Y, Nagano H, Marubashi S, et al. Sclerosing epithelioid fibrosarcoma of the liver infiltrating the inferior vena cava[J]. World J Gastroenterol, 2009, 15(33): 4204-4208.
5.	Frattini JC, Sosa JA, Carmack S, et al. Sclerosing epithelioid fibrosarcoma of the cecum: a radiation-associated tumor in a previously unreported site[J]. Arch Pathol Lab Med, 2007, 131(12): 1825-1828.
6.	Hanson IM, Pearson JM, Eyden BP, et al. Evidence of nerve sheath diferentiation and high grade morphology in sclerosing epithelioid fibrosarcoma[J]. J Clin Pathol, 2001, 54(9): 721-723.
7.	Rekhi B, Deshmukh M, Jambhekar NA. Low-grade fibromyxoid sarcoma: a clinicopathologic study of 18 cases, including histopathologic relationship with sclerosing epithelioid fibrosarcoma in a subset of cases[J]. Ann Diagn Pathol, 2011, 15(5): 303-311.
8.	Massier A, Scheithauer BW, Taylor HC, et al. Sclerosing epithelioid fibrosarcoma of the pituitary[J]. Endocr Pathol, 2007,18(4): 233-238.
9.	Jiao YF, Nakamura S, Sugai T, et al. Overexpression of MDM2 in a sclerosing epithelioid fibrosarcoma: genetic, immunohistochemical and ultrastructural study of a case[J]. Pathol Int, 2002, 52(2): 135-140.
10.	Ogose A, Kawashima H, Umezu H, et al. Schrosing epithelioid Fibrosarcoma with der(10)t(10；17)(p11；q11)[J]. Cancer Genet Cytogenet, 2004, 152(2): 136-140.
11.	Wang WL, Evans HL, Meis JM, et al. FUS rearrangements are rare in ‘pure’ sclerosing epithelioid fibrosarcoma[J]. Mod Pathol, 2012, 25(6): 846-853.
12.	Yoon N, Kwon JW, Seo SW, et al. Sclerosing epithelioid fibrosarcoma: cytogenetic analysis of FUS rearrangement[J]. Pathol Int, 2012, 62(1): 65-68.
13.	Elkins CT, Wakely PE Jr. Sclerosing epithelioid fibrosarcoma of the oral cavity[J]. Head Neck Pathol, 2011, 5(4): 428-431.
14.	Rekhi B, Folpe AL, Deshmukh M, et al. Sclerosing epithelioid fibrosarcoma - a report of two cases with cytogenetic analysis of FUS gene rearrangement by FISH technique[J]. Pathol Oncol Res, 2011, 17(1):145-148.

1. 　Meis-Kindblom JM, Kindblom LG, Enzinger FM. Sclerosing epithelioid fibrosarcoma: a variant of fibrosarcoma simulating carcinoma[J]. Am J Surg Pathol, 1995, 19(9): 979-993.
2. 　Folk GS, Williams SB, Foss RB, et al. Oral and maxillofacial sclerosing epithelioid fibroscarcoma: report of five cases[J]. Head Neck Pathol, 2007, 1(1): 13-20.
3. 　Ossendorf C, Studer GM, Bode B, et al. Sclerosing epithelioid fibrosarcoma: case presentation and a systematic review[J]. Clin Orthop Relat Res, 2008, 466(6): 1485-1491.
4. 　Tomimaru Y, Nagano H, Marubashi S, et al. Sclerosing epithelioid fibrosarcoma of the liver infiltrating the inferior vena cava[J]. World J Gastroenterol, 2009, 15(33): 4204-4208.
5. 　Frattini JC, Sosa JA, Carmack S, et al. Sclerosing epithelioid fibrosarcoma of the cecum: a radiation-associated tumor in a previously unreported site[J]. Arch Pathol Lab Med, 2007, 131(12): 1825-1828.
6. 　Hanson IM, Pearson JM, Eyden BP, et al. Evidence of nerve sheath diferentiation and high grade morphology in sclerosing epithelioid fibrosarcoma[J]. J Clin Pathol, 2001, 54(9): 721-723.
7. 　Rekhi B, Deshmukh M, Jambhekar NA. Low-grade fibromyxoid sarcoma: a clinicopathologic study of 18 cases, including histopathologic relationship with sclerosing epithelioid fibrosarcoma in a subset of cases[J]. Ann Diagn Pathol, 2011, 15(5): 303-311.
8. 　Massier A, Scheithauer BW, Taylor HC, et al. Sclerosing epithelioid fibrosarcoma of the pituitary[J]. Endocr Pathol, 2007,18(4): 233-238.
9. 　Jiao YF, Nakamura S, Sugai T, et al. Overexpression of MDM2 in a sclerosing epithelioid fibrosarcoma: genetic, immunohistochemical and ultrastructural study of a case[J]. Pathol Int, 2002, 52(2): 135-140.
10. 　Ogose A, Kawashima H, Umezu H, et al. Schrosing epithelioid Fibrosarcoma with der(10)t(10；17)(p11；q11)[J]. Cancer Genet Cytogenet, 2004, 152(2): 136-140.
11. 　Wang WL, Evans HL, Meis JM, et al. FUS rearrangements are rare in ‘pure’ sclerosing epithelioid fibrosarcoma[J]. Mod Pathol, 2012, 25(6): 846-853.
12. 　Yoon N, Kwon JW, Seo SW, et al. Sclerosing epithelioid fibrosarcoma: cytogenetic analysis of FUS rearrangement[J]. Pathol Int, 2012, 62(1): 65-68.
13. 　Elkins CT, Wakely PE Jr. Sclerosing epithelioid fibrosarcoma of the oral cavity[J]. Head Neck Pathol, 2011, 5(4): 428-431.
14. 　Rekhi B, Folpe AL, Deshmukh M, et al. Sclerosing epithelioid fibrosarcoma - a report of two cases with cytogenetic analysis of FUS gene rearrangement by FISH technique[J]. Pathol Oncol Res, 2011, 17(1):145-148.

《華西醫學》

硬化性上皮樣纖維肉瘤臨床病理分析

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《華西醫學》

硬化性上皮樣纖維肉瘤臨床病理分析

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