細胞外基質在長段氣管病損治療中的應用與研究進展_《中國胸心血管外科臨床雜志》

作者：

章方彪 , 張衛東 , 史宏燦

揚州大學臨床醫學院　胸外科，江蘇　揚州　225001;

關鍵詞：

細胞外基質　主動脈　氣管　生物復合材料

DOI：

10.7507/1007-4848.20130099

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

氣管的病損超過一定的長度則需要進行氣管移植。傳統采用天然組織和自體組織替代氣管，因局部感染、氣管狹窄、氣管軟化和免疫排斥反應等因素均未能獲得良好的療效。近年來，組織工程氣管的出現為氣管移植提供了新的思路，但選擇理想的細胞外基質用于構建組織工程氣管尚未達成統一的意見。目前，在氣管組織工程領域研究和應用的細胞外基質主要包括同種異體氣管基質、同種異體主動脈基質和生物復合材料。采用不同方法獲得的同種異體基質及生物復合材料各具有其優勢及劣勢。本文主要針對細胞外基質在長段氣管病損治療中的應用、研究進展及未來前景進行綜述。

引用本文： 章方彪,張衛東,史宏燦. 細胞外基質在長段氣管病損治療中的應用與研究進展. 中國胸心血管外科臨床雜志, 2013, 20(3): 334-337. doi: 10.7507/1007-4848.20130099 復制

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23.	Agarwal S，Wendorff JH，Greiner A. Progress in the field of electrospinning for tissue engineering applications. Adv Mater，2009，21 （32-33）：3343-3351.
24.	Li MY，Mondrinos MJ，Gandhi MR，et al. Electrospun protein fibers as matrices for tissue engineering. Biomaterials，2005，26 （30）：5999-6008.
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26.	Grafahrend D，Heffels KH，Beer MV，et al. Degradable polyester scaffolds with controlled surface chemistry combining minimal protein adsorption with specific bioactivation. Nat Mater，2011，10 （1）：67-73.
27.	Rnjak-Kovacina J，Weiss AS. Increasing the pore size of electrospun scaffolds. Tissue Eng Part B Rev，2011，17 （5）：365-372.
28.	Hinderer S，Schesny M，Bayrak A，et al. Engineering of fibrillar decorin matrices for a tissue-engineered trachea. Biomaterials，2012，33 （21）：5259-5266.
29.	Baiguera S，Del Gaudio C，Jaus MO，et al. Long-term changes to in vitro preserved bioengineered human trachea and their implications for decellularized tissues. Biomaterials，2012，33 （14）：3662-3672.

1. 　Kalathur M，Baiguera S，Macchiarini P. Translating tissue-engineered tracheal replacement from bench to bedside. Cell Mol Life Sci，2010，67 （24）：4185-4196.
2. 　Jungebluth P，Alici E，Baiguera S，et al. Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite：a proof-of-concept study. Lancet，2011，378 （9808）：1997-2004.
3. 　Jungebluth P，Bader A，Baiguera S，et al. The concept of in vivo airway tissue engineering. Biomaterials，2012，33 （17）：4319-4326.
4. 　Go T，Jungebluth P，Baiguero S，et al. Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. J Thorac Cardiovasc Surg，2010，139 （2）：437-443.
5. 　Macchiarini P，Jungebluth P，Go T，et al. Clinical transplantation of a tissue-engineered airway. Lancet，2008，372 （9655）：2023-2030.
6. 　Conconi MT，De Coppi P，Di Liddo R，et al. Tracheal matrices，obtained by a detergent-enzymatic method，support in vitro the adhesion of chondrocytes and tracheal epithelial cells. Transpl Int，2005，18 （6）：727-734.
7. 　Shi HC，Xu H，Lu D，et al. Animal models of tracheal allotransplantation using vitrified cryopreservation. J Thorac Cardiovasc Surg，2009，138 （5）：1222-1226.
8. 　Han Y，Lan N，Pang CJ，et al. Bone marrow-derived mesenchymal stem cells enhance cryopreserved trachea allograft epithelium regeneration and vascular endothelial growth factor expression. Transplantation，2011，92 （6）：620-626.
9. 　Liu Y，Yang Y，Ding JY，et al. Ultrastructural changes in cryopreserved tracheal grafts of sprague-dawley rats. ASAIO J，2009，55 （5）：509-513.
10. 　Haag J，Baiguera S，Jungebluth P，et al. Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue. Biomaterials，2012，33 （3）：780-789.
11. 　Baiguera S，Jungebluth P，Burns A，et al. Tissue engineered human tracheas for in vivo implantation. Biomaterials，2010，31 （34）：8931-8938.
12. 　Delaere P，Vrancks J，Verleden G，et al. Tracheal allotransplantation after withdrawal of immunosuppressive therapy. N Engl J Med，2010，194 （7）：1335-1337.
13. 　Wurtz A，Porte H，Conti M，et al. Surgical technique and results of tracheal and carinal replacement with aortic allografts for salivary gland-type carcinoma. J Thorac Cardiovasc Surg，2010，140 （2）：387-393.
14. 　Tsukada H，Ernst A，Gangadharan S，et al. Tracheal replacement with a silicone-stented，fresh aortic allograft in sheep. Ann Thorac Surg，2010，89 （1）：253-258.
15. 　Makris D，Holder-Espinasse M，Wurtz A，et al. Tracheal replacement with cryopreserved allogenic aorta. Chest，2010，137 （1）：60-67.
16. 　Kim DH，Choi CB，Yang WJ，et al. Tracheal replacement with fresh and cryopreserved aortic allograft in adult dog. J Surg Res，2012，175 （2）：199-206.
17. 　Seguin A，Radu D，Holder-Espinasse M，et al. Tracheal replacement with cryopreserved，decellularized，or glutaraldehyde-treated aortic allografts. Ann Thorac Surg，2009，87 （3）：861-867.
18. 　Wang YC，Wong LB，Mao H. Creation of a long-lifespan ciliated epithelial tissue structure using a 3D collagen scaffold. Biomaterials，2010，31 （5）：848-853.
19. 　Alves da Silva ML，Crawford A，Mundy JM，et al. Chitosan/polyester-based scaffolds for cartilage tissue engineering：assessment of extracellular matrix formation. Acta Biomater，2010，6 （3）：1149-1157.
20. 　Cui L，Wu YH，Cen L，et al. Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh. Biomaterials，2009，30 （14）：2683-2693.
21. 　Liu LQ，Wu W，Tuo XY，et al. Novel strategy to engineer trachea cartilage graft with marrow mesenchymal stem cell macroaggregate and hydrolyzable scaffold. Artif Organs，2010，34 （5）：426-433.
22. 　Jungebluth P，Moll G，Baiguera S，et al. Tissue-engineered airway：a regenerative solution. Clin Pharmacol Ther，2012，91 （1）：81-93.
23. 　Agarwal S，Wendorff JH，Greiner A. Progress in the field of electrospinning for tissue engineering applications. Adv Mater，2009，21 （32-33）：3343-3351.
24. 　Li MY，Mondrinos MJ，Gandhi MR，et al. Electrospun protein fibers as matrices for tissue engineering. Biomaterials，2005，26 （30）：5999-6008.
25. 　Chen ZG，Wang PW，Wei B，et al. Electrospun collagen-chitosan nanofiber：a biomimetic extracellular matrix for endothelial cell and smooth cell and smooth muscle cell. Acta Biomaterials，2010，6 （2）：372-382.
26. 　Grafahrend D，Heffels KH，Beer MV，et al. Degradable polyester scaffolds with controlled surface chemistry combining minimal protein adsorption with specific bioactivation. Nat Mater，2011，10 （1）：67-73.
27. 　Rnjak-Kovacina J，Weiss AS. Increasing the pore size of electrospun scaffolds. Tissue Eng Part B Rev，2011，17 （5）：365-372.
28. 　Hinderer S，Schesny M，Bayrak A，et al. Engineering of fibrillar decorin matrices for a tissue-engineered trachea. Biomaterials，2012，33 （21）：5259-5266.
29. 　Baiguera S，Del Gaudio C，Jaus MO，et al. Long-term changes to in vitro preserved bioengineered human trachea and their implications for decellularized tissues. Biomaterials，2012，33 （14）：3662-3672.

《中國胸心血管外科臨床雜志》

細胞外基質在長段氣管病損治療中的應用與研究進展

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《中國胸心血管外科臨床雜志》

細胞外基質在長段氣管病損治療中的應用與研究進展

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