MnSOD基因Val-9Ala多態性與乳腺癌易感性關系的Meta分析_《中國循證醫學雜志》

作者：

孫國貴 ¹ ,  王雅棣 ² , 王士杰 ³ , 鄭明民 ² , 程云杰 ³ , 李成林 ³ , 柴紅 ⁴

1.河北省唐山市人民醫院放化療科（唐山?063000）；2.北京軍區總醫院放療科（北京?100700）；3. 河北醫科大學第四醫院放療科（石家莊?050011）；4.唐山市工人醫院內分泌一科（唐山?063000）;

關鍵詞：

錳超氧化物歧化酶乳腺癌基因多態性腫瘤易感性 Meta分析

DOI：

10.7507/1672-2531.20110172

視頻：

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目的　評價錳超氧化物歧化酶（MnSOD）基因Val-9Ala多態性與乳腺癌易感性及經期狀態的關系。
方法　計算機檢索Cochrane Library（2010年第1期）、PubMed、CNKI、CBM和萬方數據庫，按照納入與排除標準選擇相關的病例對照試驗，檢索時限均為建庫至2010 年10月。在提取資料和評價質量后，采用RevMan 4.2.10軟件進行Meta分析。
結果　共納入14個研究，合計17 842例患者。Meta分析結果顯示，MnSOD基因Val-9Ala多態性與乳腺癌易感性無關［Val/Ala vs. Val/Val：OR=1.04，95%CI（0.93，1.17）； Ala/Ala vs. Val/Val：OR=1.12，95%CI（0.95，1.33）；Ala/Ala vs. Val/Ala+Val/Val：OR=1.06，95%CI（0.93，1.20）；Val/Ala+ Ala/Ala vs. Val/Val：OR=1.06，95%CI（0.94，1.10）］。進一步亞組分析結果顯示，MnSOD Val/Ala及Ala/Ala基因型會增加絕經前婦女患乳腺癌的風險［Val/Ala+Ala/Ala vs. Val/Val：OR=1.15，95%CI（1.01，1.31）］。
結論　MnSOD基因Val-9Ala多態性與乳腺癌易感性無關，但可能增加絕經前婦女患乳腺癌的風險。

引用本文： 孫國貴,王雅棣,王士杰,鄭明民,程云杰,李成林,柴紅. MnSOD基因Val-9Ala多態性與乳腺癌易感性關系的Meta分析. 中國循證醫學雜志, 2011, 11(9): 1027-1032. doi: 10.7507/1672-2531.20110172 復制

1.	1 Debruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environ Health Perspect , 2002, 110(suppl1): 119-128.
2.	Knight JA, Onay UV, Wells S, et al . Genetic variants of GPX1 and SOD2 and breast cancer risk at the ontario site of the breast cancer family registry. Cancer Epidemiol Biomarkers Prev , 2004 13(1): 146-149.
3.	Woodson K, Tangrea JA, Lehman TA, et al . Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland). Cancer Causes Control , 2003, 14(6): 513-518.
4.	吳曉梅, 時玥, 時景璞, 等. 中國漢族人群腦出血患者血管緊張素轉換酶基因插入/缺失多態性的Meta分析. 中國循證醫學雜志, 2009, 9(12): 1323-1327.
5.	Ambrosone CB, Freudenheim JL, Thompson PA, et al . Manganese superoxide dismutase (MnSOD) geneticpolymorphisms, dietary antioxidants, and risk of breastcancer. Cancer Res , 1999, 59(3): 602-606.
6.	Mitrunen K, Sillanpaa P, Kataja V, et al . Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk. Carcinogenesis , 2001, 22(5): 827-829.
7.	Egan KM, Thompson PA, Titus-Ernstoff L, et al . MnSOD polymorphism and breast cancer in a population-based case–control study. Cancer Lett , 2003, 199(1): 27-33.
8.	Cai Q, Shu XO, Wen W, et al . Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Breast Cancer Res , 2004, 6(6): 647-655.
9.	Millikan RC, Player J, De Coftret AR, et al . Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites. Breast Cancer Res , 2004, 6(4): 264-274.
10.	Tamimi RM, Hankinson SE, Spiegelman D, et al . Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev , 2004, 13(6): 989-996.
11.	Bergman M, Ahnstrom M, Palmeba CK, et al . Polymorphism in the manganese superoxidedismutase (MnSOD) gene and risk of breast cancer in young women. J Cancer Res Clin Oncol , 2005, 131(7): 439-444.
12.	Cheng TC, Chen ST, Huang CS, et al . Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: A multigenic study on cancer susceptibility. Int J Cancer , 2005, 113(3): 345-353.
13.	Gaudet MM, Gammon MD, Santella RM, et al . MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York. Cancer Causes Control , 2005, 16(10): 1225-1234.
14.	Kocabas NA, Sardas S, Cholerton S, et al . Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility. Cell Biochem Funct , 2005, 23(1): 73-76.
15.	Slanger TE, Chang-Claude J, Wang-Gohrke S. Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population. Cancer Causes Control , 2006, 17(8): 1025-1031.
16.	Bica CG. Association of manganese superoxide dismutase gene polymorphism (Ala-9Val) and breastcancer in males and females. J Bras Patol Med Lab , 2007, 43(3): 219-225.
17.	Bica CG. MnSOD Gene polymorphism association with steroid-dependent cancer. Pathol Oncol Res , 2009, 15(1): 19-24.
18.	Eras-Erdogan N, Akbas E, Senli H, et al . Relationship between polymorphism in the manganese superoxide dismutase gene and breast cancer. Mutation Research , 2009, 680(1-2): 7-11.
19.	Trachootham D, Lu W, Ogasawara MA, et al . Redox regulation of cell survival. Antioxid Redox Signal , 2008, 10(8): 1343-1374.
20.	Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol , 2007, 47(N): 143-183.
21.	Sutton A, Khoury H, Prip-Buus C, et al . The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics , 2003, 13(3): 145-157.
22.	Wang LI, Miller DP, Sai Y, et al . Manganese superoxide dismutase alanine- to-valine polymorphism at codon 16 and lung cancer risk. J Natl Cancer Inst , 2001, 93(23): 1818-1821.
23.	程云杰, 王雅棣, 劉青, 等. 超氧化物歧化酶基因的多態性與食管的發生發展關系. 中華腫瘤雜志, 2009, 31(11): 831-835.
24.	Robert CG, Martin MD, Qing L, et al . No apparent association between genetic polymorphisms (–102 C>T) and (–9 T>C) in the human manganese superoxide dismutase gene and gastric cancer. J Surg Res , 2005, 124(1): 92-97.
25.	Lin P, Hsueh YM, Ko JL, et al . Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan. Lung Cancer , 2003, 40(2): 123-129.

1. 1 Debruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environ Health Perspect , 2002, 110(suppl1): 119-128.
2. Knight JA, Onay UV, Wells S, et al . Genetic variants of GPX1 and SOD2 and breast cancer risk at the ontario site of the breast cancer family registry. Cancer Epidemiol Biomarkers Prev , 2004 13(1): 146-149.
3. Woodson K, Tangrea JA, Lehman TA, et al . Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland). Cancer Causes Control , 2003, 14(6): 513-518.
4. 吳曉梅, 時玥, 時景璞, 等. 中國漢族人群腦出血患者血管緊張素轉換酶基因插入/缺失多態性的Meta分析. 中國循證醫學雜志, 2009, 9(12): 1323-1327.
5. Ambrosone CB, Freudenheim JL, Thompson PA, et al . Manganese superoxide dismutase (MnSOD) geneticpolymorphisms, dietary antioxidants, and risk of breastcancer. Cancer Res , 1999, 59(3): 602-606.
6. Mitrunen K, Sillanpaa P, Kataja V, et al . Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk. Carcinogenesis , 2001, 22(5): 827-829.
7. Egan KM, Thompson PA, Titus-Ernstoff L, et al . MnSOD polymorphism and breast cancer in a population-based case–control study. Cancer Lett , 2003, 199(1): 27-33.
8. Cai Q, Shu XO, Wen W, et al . Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Breast Cancer Res , 2004, 6(6): 647-655.
9. Millikan RC, Player J, De Coftret AR, et al . Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites. Breast Cancer Res , 2004, 6(4): 264-274.
10. Tamimi RM, Hankinson SE, Spiegelman D, et al . Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev , 2004, 13(6): 989-996.
11. Bergman M, Ahnstrom M, Palmeba CK, et al . Polymorphism in the manganese superoxidedismutase (MnSOD) gene and risk of breast cancer in young women. J Cancer Res Clin Oncol , 2005, 131(7): 439-444.
12. Cheng TC, Chen ST, Huang CS, et al . Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: A multigenic study on cancer susceptibility. Int J Cancer , 2005, 113(3): 345-353.
13. Gaudet MM, Gammon MD, Santella RM, et al . MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York. Cancer Causes Control , 2005, 16(10): 1225-1234.
14. Kocabas NA, Sardas S, Cholerton S, et al . Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility. Cell Biochem Funct , 2005, 23(1): 73-76.
15. Slanger TE, Chang-Claude J, Wang-Gohrke S. Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population. Cancer Causes Control , 2006, 17(8): 1025-1031.
16. Bica CG. Association of manganese superoxide dismutase gene polymorphism (Ala-9Val) and breastcancer in males and females. J Bras Patol Med Lab , 2007, 43(3): 219-225.
17. Bica CG. MnSOD Gene polymorphism association with steroid-dependent cancer. Pathol Oncol Res , 2009, 15(1): 19-24.
18. Eras-Erdogan N, Akbas E, Senli H, et al . Relationship between polymorphism in the manganese superoxide dismutase gene and breast cancer. Mutation Research , 2009, 680(1-2): 7-11.
19. Trachootham D, Lu W, Ogasawara MA, et al . Redox regulation of cell survival. Antioxid Redox Signal , 2008, 10(8): 1343-1374.
20. Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol , 2007, 47(N): 143-183.
21. Sutton A, Khoury H, Prip-Buus C, et al . The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics , 2003, 13(3): 145-157.
22. Wang LI, Miller DP, Sai Y, et al . Manganese superoxide dismutase alanine- to-valine polymorphism at codon 16 and lung cancer risk. J Natl Cancer Inst , 2001, 93(23): 1818-1821.
23. 程云杰, 王雅棣, 劉青, 等. 超氧化物歧化酶基因的多態性與食管的發生發展關系. 中華腫瘤雜志, 2009, 31(11): 831-835.
24. Robert CG, Martin MD, Qing L, et al . No apparent association between genetic polymorphisms (–102 C>T) and (–9 T>C) in the human manganese superoxide dismutase gene and gastric cancer. J Surg Res , 2005, 124(1): 92-97.
25. Lin P, Hsueh YM, Ko JL, et al . Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan. Lung Cancer , 2003, 40(2): 123-129.

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MnSOD基因Val-9Ala多態性與乳腺癌易感性關系的Meta分析

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《中國循證醫學雜志》

MnSOD基因Val-9Ala多態性與乳腺癌易感性關系的Meta分析

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