青春期攝入豆類食品對女性乳腺癌發病影響的系統評價_《中國循證醫學雜志》

作者：

趙陽 ¹ , 潘建紅 ² ,  張立力 ¹

1. 南方醫科大學護理學院（廣州 510515）；2. 南方醫科大學公共衛生與熱帶醫學學院生物統計學系（廣州 510515）;

關鍵詞：

青春期豆類食品乳腺癌 Meta分析系統評價

DOI：

10.7507/1672-2531.20120089

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　系統評價青春期攝入豆類食品對女性成年后乳腺癌發病影響。
方法　計算機檢索Cochrane Library、MEDLINE、EMbase、CNKI、VIP、WanFang Data和CBM中關于青春期食用豆類食品對女性成年后乳腺癌發病影響的隊列研究和病例對照研究，同時追索納入文獻的參考文獻。文獻檢索起止時間均為從建庫至2011年8月。由兩名研究者嚴格按照納入和排除標準篩選文獻、提取資料，并根據Cochrane協作網推薦的Newcastle-Ottawa scale（NOS）和GRADE系統推薦的分級方法進行質量評價，對符合標準的研究進行Meta 分析。最后采用Stata 11.0和GRADE profiler 3.2.2 軟件進行統計分析。
結果　共納入6個研究，6 609例病例和79 538例對照。Meta分析結果顯示，青春期食用豆類食品較多的女性比青春期不食用或很少食用豆類食品的女性成年后乳腺癌的發病風險低［OR=0.816，95%CI（0.670，0.993）］。亞組分析結果顯示，青春期豆類食品的攝入對絕經前乳腺癌的預防作用［OR=0.661，95%CI（0.550，0.796）］強于絕經后［OR=0.782，95%CI（0.486，1.259）］；而無論東、西方女性攝入豆類食品均受益［OR=0.793，95%CI（0.569，1.105）；OR=0.837，95%CI（0.743，0.943）］。
結論　青春期食用豆類食品對女性成年后乳腺癌發病可能具有一定的預防作用，且對絕經前乳腺癌的預防作用尤其明顯，而無論東、西方女性均受益。受納入研究數量與質量的限制，上述結論尚需進一步驗證。

引用本文： 趙陽,潘建紅,張立力. 青春期攝入豆類食品對女性乳腺癌發病影響的系統評價. 中國循證醫學雜志, 2012, 12(5): 550-556. doi: 10.7507/1672-2531.20120089 復制

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13.	Murrill WB, Brown NM, Zhang JX, et al. Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis, 1996, 17(7): 1451-1457.
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16.	Wu AH, Wan P, Hankin J, et al. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis, 2002, 23(9): 1491-1496.
17.	Thanos J, Cotterchio M, Boucher BA, et al. Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). Cancer Causes Control, 2006 , 17(10): 1253-1261.
18.	Korde LA, Wu AH, Fears T, et al. Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev, 2009 , 18(4): 1050-1059.
19.	Lee SA, Shu XO, Li HL, et al. Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women’s Health Study. Am J Clin Nutr, 2009, 89(6): 1920-1926.
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21.	Lu LJ, Anderson KE, Grady JJ, et al. Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction. Cancer Epidem Biomar, 1996, 5(1): 63.

1. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 2006, 24(14): 2137.
2. Ziegler RG, Hoover RN, Pike MC, et al. Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer I, 1993, 85(22): 1819.
3. McPherson K, Steel CM, Dixon JM. Breast cancer—epidemiology, risk factors, and genetics. BMJ, 2000, 321(7261): 624.
4. Hunter DJ, Spiegelman D, Adami HO, et al. Cohort studies of fat intake and the risk of breast cancer—a pooled analysis. New Engl J Med, 1996, 334(6): 356-361.
5. Messina M, Barnes S. The role of soy products in reducing risk of cancer. J Natl Cancer I, 1991, 83(8): 541.
6. Trock BJ, Hilakivi-Clarke L, Clarke R. Meta-analysis of soy intake and breast cancer risk. J Natl Cancer Inst, 2006, 98(7): 459-471.
7. Wu AH, Yu MC, Tseng CC, et al. Epidemiology of soy exposures and breast cancer risk. Brit J Cancer, 2008, 98(1): 9-14.
8. Dong JY, Qin LQ. Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat, 2011, 125(2): 315-323.
9. Hooper L, Ryder JJ, Kurzer MS, et al. Effects of soy protein and isoflavones on circulating hormone concentrations in pre-and post-menopausal women: a systematic review and meta-analysis. Hum Reprod Update, 2009, 15(4): 423.
10. Schedin PJ, Byers T. Adolescent diet and the risk of breast cancer in adulthood: A role for vitamin A? Nutrition, 1997, 13(10): 924-925.
11. Tyczynski J, Tarkowski W, Parkin DM, et al. Cancer mortality among Polish migrants to Australia. Eur J Cancer, 1994, 30(4): 478-484.
12. Hilakivi-Clarke L, Onojafe I, et al. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Brit J Cancer, 1999, 80(11): 1682-1688.
13. Murrill WB, Brown NM, Zhang JX, et al. Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis, 1996, 17(7): 1451-1457.
14. Potischman N, Weiss HA, Swanson CA, et al. Diet during adolescence and risk of breast cancer among young women. J Natl Cancer I, 1998, 90(3): 226-233.
15. Shu XO, Jin F, Dai Q, et al. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer epidemiology, biomarkers & prevention, 2001, 10(5): 483-488.
16. Wu AH, Wan P, Hankin J, et al. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis, 2002, 23(9): 1491-1496.
17. Thanos J, Cotterchio M, Boucher BA, et al. Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). Cancer Causes Control, 2006 , 17(10): 1253-1261.
18. Korde LA, Wu AH, Fears T, et al. Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev, 2009 , 18(4): 1050-1059.
19. Lee SA, Shu XO, Li HL, et al. Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women’s Health Study. Am J Clin Nutr, 2009, 89(6): 1920-1926.
20. Atkins D, Best D, Briss PA. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454): 1490.
21. Lu LJ, Anderson KE, Grady JJ, et al. Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction. Cancer Epidem Biomar, 1996, 5(1): 63.

《中國循證醫學雜志》

青春期攝入豆類食品對女性乳腺癌發病影響的系統評價

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《中國循證醫學雜志》

青春期攝入豆類食品對女性乳腺癌發病影響的系統評價

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