白細胞介素-28B附近基因多態性與慢性丙型肝炎的抗病毒治療相關性的研究進展_《華西醫學》

作者：

徐輝 ,  雷學忠

四川大學華西醫院感染性疾病中心生物治療國家重點實驗室感染性疾病研究室（成都，610041）;

關鍵詞：

丙型肝炎病毒白細胞介素-28B 單核苷酸多態性預測療效

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【摘要】 白細胞介素-28B（IL-28B）是一種重要的細胞因子，也被稱之為干擾素-λ3 （IFN-λ3），其作用機制類似于IFN-α，通過誘導受體異二聚體化，活化JAK-STAT信號通路，進而發揮抗病毒、免疫調節等生物學作用。最近國外研究團隊相繼發現IL-28B基因附近的單核苷酸多態性與干擾素聯合利巴韋林治療慢性丙型病毒性肝炎的療效密切相關。這有助于通過宿主基因水平更準確的預測患者治療效果，并有可能在將來提供一種更有效的治療方案。

引用本文： 徐輝,雷學忠. 白細胞介素-28B附近基因多態性與慢性丙型肝炎的抗病毒治療相關性的研究進展. 華西醫學, 2011, 26(1): 139-141. doi: 復制

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5.	Liu CH, Liu CJ, Lin CL, et al. Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trial[J]. Clin Infect Dis, 2008, 47(10): 1260-1269.
6.	Yan KK, Guirgis M, Dinh T, et al. Treatment responses in Asians and Caucasians with chronic hepatitis C infection[J]. World J Gastroenterol, 2008, 14(21): 3416-3420.
7.	Sheppard P, Kindsvogel W, Xu WF, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R[J]. Nat Immunol, 2003, 4(1): 63-68.
8.	Kotenko SV, Gallagher G, Baurin VV, et al. IFN-lambda s mediate antiviral protection through a distinct class II cytokine receptor complex[J]. Nat Immunol, 2003, 4(1): 69-77.
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13.	Marcello T, Grakoui A, Barba-spaeth G, et al. Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics[J]. Gastroenterology, 2006, 131(6): 1887-1898.
14.	Suppiah V, Moldowan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy[J]. Nat Genet, 2009, 41(10): 1100-1174.
15.	Tanaka Y, Nishida N, Sugiyama M, et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C[J]. Na Genet, 2009, 41(10): 1105-1181.

1. 　Ghany MG, Strader DB, Thomas DL, et al. Diagnosis, management, and treatment of hepatitis C: an update[J]. Hepatology, 2009, 49(4): 1335-1374.
2. 　Amin J, Dore GJ, O’connell DL, et al. Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study[J]. J Hepatol, 2006, 45(2): 197-203.
3. 　Zeuzem S, Berg T, Moeller B, et al. Expert opinion on the treatment of patients with chronic hepatitis C[J]. J Viral Hepatitis, 2009, 16(2): 75-90.
4. 　Hadziyannis SJ, Sette H, Morgan TR, et al. Peginterferon-alpha 2a and ribavirin combination therapy in chronic hepatitis C - A randomized study of treatment duration and ribavirin dose[J]. Ann Intern Med, 2004, 140(5): 346-355.
5. 　Liu CH, Liu CJ, Lin CL, et al. Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trial[J]. Clin Infect Dis, 2008, 47(10): 1260-1269.
6. 　Yan KK, Guirgis M, Dinh T, et al. Treatment responses in Asians and Caucasians with chronic hepatitis C infection[J]. World J Gastroenterol, 2008, 14(21): 3416-3420.
7. 　Sheppard P, Kindsvogel W, Xu WF, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R[J]. Nat Immunol, 2003, 4(1): 63-68.
8. 　Kotenko SV, Gallagher G, Baurin VV, et al. IFN-lambda s mediate antiviral protection through a distinct class II cytokine receptor complex[J]. Nat Immunol, 2003, 4(1): 69-77.
9. 　Ge DL, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance[J]. Nature, 2009, 461(7262): 399-401.
10. 　Thomas DL, Thio CL, Martin MP, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus[J]. Nature, 2009, 461(7265): 798-801.
11. 　Robek MD, Boyd BS, Chisari FV. Lambda interferon inhibits hepatitis B and C virus replication[J]. J Virol, 2005, 79(6): 3851-3854.
12. 　Ank N, West H, Bartholdy C, et al. Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo[J]. J Virol, 2006, 80(9): 4501-4509.
13. 　Marcello T, Grakoui A, Barba-spaeth G, et al. Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics[J]. Gastroenterology, 2006, 131(6): 1887-1898.
14. 　Suppiah V, Moldowan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy[J]. Nat Genet, 2009, 41(10): 1100-1174.
15. 　Tanaka Y, Nishida N, Sugiyama M, et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C[J]. Na Genet, 2009, 41(10): 1105-1181.

《華西醫學》

白細胞介素-28B附近基因多態性與慢性丙型肝炎的抗病毒治療相關性的研究進展

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《華西醫學》

白細胞介素-28B附近基因多態性與慢性丙型肝炎的抗病毒治療相關性的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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