毒蕈中毒致中毒性肝炎3例臨床分析_《華西醫學》

作者：

史映紅 , 馮萍

四川大學華西醫院感染性疾病中心，四川成都 610041;

關鍵詞：

毒蕈中毒中毒性肝炎血漿置換肝移植

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目的：探討毒蕈中毒所致中毒性肝炎的臨床表現、治療與預后關系。方法：對3例急性毒蕈中毒患者進行回顧性臨床分析。結果：3例患者均出現中毒性肝炎，2例經治療后好轉，1例因多器官功能衰竭死亡。結論：中毒性肝炎如導致多臟器損害，預后差；及早洗胃，徹底清除毒物是救治關鍵；血漿置換治療有一定療效，肝移植是最有效的治療手段。

引用本文： 史映紅,馮萍. 毒蕈中毒致中毒性肝炎3例臨床分析. 華西醫學, 2008, 23(1): 118-119. doi: 復制

1.	[１]Iliev Y,Andonova SA,Kabaliev V.Our experience in the treatment of acute amanita phalloides poisoning[Ｊ].Folia Med (Plovdiv),1999,41(4):30．.
2.	陳灝珠.實用內科學[M].第10版，北京:人民衛生出版社,1998：711．.
3.	Sanford T,Golomb M.RNA polymerase 2 from wildtype and a-amanitin-resistant strains of Caenorhabditis elegans[Ｊ].J Biol Chem,1983,258(21):12804．〖ＨＪ０．４２ｍｍ〗.
4.	Schumann J,Tiegs G.Pathophysiological mechanisms of TNF during intoxication with natural or man-made toxins[Ｊ]．Toxicology，1999,138:103．.
5.	Leist M,Gantner F，Bohlinger I,et al.murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest[Ｊ].J Immunol,1994,153(4):1778-1788．.
6.	Laskin DL.Nonparenchymal cells and hepatotoxicity[Ｊ].Semin Liver Dis,1990,10:293．.
7.	Catalina MV,Núnez O,Ponferrada A,et al.Liver failure due to mushroom poisoning:clinical course and new treatment perspectives[Ｊ].Gastroenterol Hepatol,2003,26(7):417-420..
8.	Enjalbert F,Rapior S,Nouguier-Soulé J,et al.Treatment of amatoxin poisoning:20-year retrospective analysis[Ｊ].Toxicol Clini Toxicol,2002,40(6):715-757..
9.	Broussard CN,Aggarwal A,Lacey SR,et al.Mushroom poisoning-from diarrhea to liver transplantation[Ｊ].Am J Gastroenterol,2001,96(11):3195-3198..
10.	Jander S,Bischoff J.Treatment of Amanita phalloides poisoning:I.Retrospective evaluation of plasmapheresis in 21 patients[Ｊ].Ther Apher，2000,4(4):303-307..
11.	張文武.急診內科學[Ｍ]．第1版，北京:人民衛生出版社,2000：568－569．.
12.	Mullins ME,Horowitz BZ.The futility of hemoperfusion and hemodialysis in amanita phalloides poisoning[Ｊ].Vet Hum Toxicol,2000,42(2):90．.

1. [１]Iliev Y,Andonova SA,Kabaliev V.Our experience in the treatment of acute amanita phalloides poisoning[Ｊ].Folia Med (Plovdiv),1999,41(4):30．.
2. 陳灝珠.實用內科學[M].第10版，北京:人民衛生出版社,1998：711．.
3. Sanford T,Golomb M.RNA polymerase 2 from wildtype and a-amanitin-resistant strains of Caenorhabditis elegans[Ｊ].J Biol Chem,1983,258(21):12804．〖ＨＪ０．４２ｍｍ〗.
4. Schumann J,Tiegs G.Pathophysiological mechanisms of TNF during intoxication with natural or man-made toxins[Ｊ]．Toxicology，1999,138:103．.
5. Leist M,Gantner F，Bohlinger I,et al.murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest[Ｊ].J Immunol,1994,153(4):1778-1788．.
6. Laskin DL.Nonparenchymal cells and hepatotoxicity[Ｊ].Semin Liver Dis,1990,10:293．.
7. Catalina MV,Núnez O,Ponferrada A,et al.Liver failure due to mushroom poisoning:clinical course and new treatment perspectives[Ｊ].Gastroenterol Hepatol,2003,26(7):417-420..
8. Enjalbert F,Rapior S,Nouguier-Soulé J,et al.Treatment of amatoxin poisoning:20-year retrospective analysis[Ｊ].Toxicol Clini Toxicol,2002,40(6):715-757..
9. Broussard CN,Aggarwal A,Lacey SR,et al.Mushroom poisoning-from diarrhea to liver transplantation[Ｊ].Am J Gastroenterol,2001,96(11):3195-3198..
10. Jander S,Bischoff J.Treatment of Amanita phalloides poisoning:I.Retrospective evaluation of plasmapheresis in 21 patients[Ｊ].Ther Apher，2000,4(4):303-307..
11. 張文武.急診內科學[Ｍ]．第1版，北京:人民衛生出版社,2000：568－569．.
12. Mullins ME,Horowitz BZ.The futility of hemoperfusion and hemodialysis in amanita phalloides poisoning[Ｊ].Vet Hum Toxicol,2000,42(2):90．.

《華西醫學》

毒蕈中毒致中毒性肝炎3例臨床分析

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《華西醫學》

毒蕈中毒致中毒性肝炎3例臨床分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料