腫瘤干細胞與胃腸道癌發生和轉移_《中國普外基礎與臨床雜志》

作者：

張鵬 , 俞繼衛 , 姜波健

上海交通大學醫學院附屬第三人民醫院普外科（上海 201900）;

關鍵詞：

胃腸道新生物癌干細胞轉移

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的介紹腫瘤干細胞在胃腸道腫瘤發生和轉移中的研究進展。
方法收集國內、外近年來有關腫瘤干細胞與胃腸道腫瘤發生與轉移的研究進展的文獻并作綜述。
結果近年來的研究已發現在腫瘤細胞中存在著少量的具有干細胞樣特性的腫瘤細胞。這些腫瘤干細胞利用機體的干細胞-巢系統而在腫瘤的發生、維持生長、增殖、轉移和復發中起著重要作用。此外，在耐受抗腫瘤藥物而導致的復發中發揮重要作用。在胃腸道腫瘤中，特別是在結直腸癌中，這些腫瘤起始細胞通常具有CD133+的特征。CD133+結腸癌細胞具有克隆形成能力、增殖能力、分化能力以及轉移瘤形成能力。同時，在骨轉移患者的外周血中也已發現有高含量的CD133 mRNA存在。
結論 CD133+腫瘤細胞的分子生物學特性以及腫瘤干細胞-巢系統的機理是開發更有效的腫瘤診治方法的基礎，并為靶向治療等新途徑提供理論依據。

引用本文： 張鵬,俞繼衛,姜波健. 腫瘤干細胞與胃腸道癌發生和轉移. 中國普外基礎與臨床雜志, 2009, 16(1): 81-84. doi: 復制

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1. 29 Takaishi S, Okumura T, Wang TC. Gastric cancer stem cell [J] . J Clin Oncol, 2008; 26(17)： 2876 30 Houghton J, Stoicov C, Nomura S, et al . Gastric cancer originating from bone marrow-derived cells [J] . Science, 2004; 306(5701)： 1568.
2. Hanahan D, Weinberg RA. The hallmarks of cancer [J] . Cell, 2000; 100(1)：57.
3. DAmour KA, Gage FH. Are somatic stem cells pluripotent or lineage-restricted? [J] . Nat Med, 2002; 8(3)： 213.
4. Singh SK, Hawkins C, Clarke ID, et al . Identification of human brain tumour initiating cells [J] . Nature, 2004; 432(7015)：396.
5. Lapidot T, Sirard C, Vormoor J, et al . A cell initiating human acute myeloid leukaemia after transplantation into SCID mice [J] . Nature, 1994; 367(6464)： 645.
6. Park CH, Bergsagel DE, McCulloch EA. Mouse myeloma tumor stem cells: a primary cell culture assay [J] . J Natl Cancer Inst, 1971; 46(2)： 411.
7. OBrien CA, Pollett A, Gallinger S, et al . A human colon cancer cell capable of initiating tumour growth in immunodeficient mice [J] . Nature, 2006; 445(7123)： 106.
8. Collins AT, Berry PA, Hyde C, et al . Prospective identification of tumorigenic prostate cancer stem cells [J] . Cancer Res, 2005; 65(23)： 10946.
9. Suetsugu A, Nagaki M, Aoki H, et al . Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells [J] . Biochem Biophys Res Commun, 2006; 351(4) ∶820.
10. Yin S, Li J, Hu C, et al . CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity [J] . Int J Cancer, 2007; 120(7)： 1444.
11. Haraguchi N, Ishikawa K, Kabahara Y, et al . Cancer stem cell and cancer metastasis [J] . Surgery Frontier , 2007; 14(4)： 60.
12. Hiratsuka S, Nakamura K, Iwai S, et al . MMP-9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis [J] . Cancer Cell, 2002; 2(4)： 289.
13. 張建軍, 劉志明. MMP-9及TIMP-1在甲狀腺癌組織及外周血中的表達及臨床意義 [J] . 中國普外基礎與臨床雜志, 2007; 14(4)： 437.
14. 朱軍華，陶凱雄，王國斌. TNF-α對肝癌細胞VEGF和MMP-9表達的影響 [J] . 中國普外基礎與臨床雜志, 2005; 12(4)：384.
15. Müller A, Homey B, Soto H, et al . Involvement of chemokine receptors in breast cancer metastasis [J] . Nature, 2001; 410 (6824)： 50.
16. Wai PY, Kuo PC. The role of Osteopontin in tumor metastasis [J] . J Surg Res, 2004; 121(2)：228.
17. Balic M, Lin H, Young L, et al . Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype [J] . Clin Cancer Res, 2006; 12(19)： 5615.
18. Hugo H, Ackland ML, Blick T, et al . Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression [J] . J Cell Physiol, 2007; 213(2)： 374.
19. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions [J] . Nat Rev Mol Cell Biol, 2006; 7(2)： 131.
20. Coussens LM, Tinkle CL, Hanahan D, et al . MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis [J] . Cell, 2000; 103(3)： 481.
21. Lyden D, Hattori K, Dias S, et al . Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth [J] . Nat Med, 2001; 7(11)： 1194.
22. Peters BA, Diaz LA, Polyak K, et al . Contribution of bone marrow-derived endothelial cells to human tumor vasculature [J] . Nat Med, 2005; 11(3)： 261.
23. Kaplan RN, Riba RD, Zacharoulis S, et al . VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche [J] . Nature, 2005; 438(7069)： 820.
24. Zlotnik A. New insights on the role of CXCR4 in cancer metastasis [J] . J Pathol, 2008; 215(3)： 211.
25. Hemmati HD, Nakano I, Lazareff JA, et al . Cancerous stem cells can arise from pediatric brain tumors [J] . Proc Natl Acad Sci USA, 2003; 100(25)： 15178.
26. Stingl J, Eirew P, Ricketson I, et al . Purification and unique properties of mammary epithelial stem cells [J] . Nature, 2006; 439(7079)： 993.
27. Miraglia S, Godfrey W, Yin AH, et al . A novelfive-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning [J] . Blood, 1997; 90(12)： 5013.
28. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al . Identification and expansion of human colon-cancer-initiating cells [J] . Nature, 2007; 445(7123)： 111.
29. Mehra N, Penning M, Maas J, et al . Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases [J] . Clin. Cancer Res, 2006; 12(16)： 4859.
30. Corbeil D, Rper K, Hellwig A, et al . The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions [J] . J Biol Chem, 2000; 275(8)：5512.

《中國普外基礎與臨床雜志》

腫瘤干細胞與胃腸道癌發生和轉移

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

腫瘤干細胞與胃腸道癌發生和轉移

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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