急性胰腺炎發病機理的研究進展_《中國普外基礎與臨床雜志》

作者：

余文 , 吳偉 , 張少輝 , 王堯華

北京中醫藥大學東方醫院普外科（北京100078）;

關鍵詞：

急性胰腺炎發病機理

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　總結急性胰腺炎發病機理的研究進展。方法　分析近年來國內、外有關急性胰腺炎發病機理的文獻報道。結果　實驗數據表明，促炎性細胞因子和趨化因子的合成與釋放對于局部損傷和炎性介質的全身播散起著重要作用，同時提示免疫系統，包括淋巴細胞和中性粒細胞的活化，在胰腺炎的發展過程中也起一定作用。另外，胰腺在一次發病之后可以完全恢復，也可以纖維化，星狀細胞被認為在胰腺成纖維過程中起著極其重要的作用。結論　急性胰腺炎的發病機理非常復雜，在疾病發作后能夠決定其嚴重程度的因子仍然未知。

引用本文： 余文,吳偉,張少輝,王堯華. 急性胰腺炎發病機理的研究進展. 中國普外基礎與臨床雜志, 2006, 13(6): 733-736. doi: 復制

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4.	Lerch MM, Saluja AK, Dawra R, et al. Acute necrotizing pancreatitis in the opossum: earliest morphological changes involve acinar cells [J]. Gastroenterology, 1992; 103(1)∶205.
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6.	Hofbauer B, Saluja A, Lerch M, et al. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats [J]. Am J Physiol, 1998; 275(2 Pt 1)∶G352.
7.	Steer ML, Meldolesi J, Figarella C. Pancreatitis. The role of lysosomes [J]. Dig Dis Sci, 1984; 29(10)∶934.
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13.	Long J, Song N, Liu XP, et al. Nuclear factor-kappaB activation on the reactive oxygen species in acute necrotizing pancreatitic rats [J]. World J Gastroenterol, 2005; 11(27)∶4277.
14.	Jeyarajah DR, Kielar M, Gokaslan ST, et al. Fas deficiency exacerbates cerulein-induced pancreatitis [J]. J Invest Surg, 2003; 16(6)∶325.
15.	Bhatia M, Wallig MA, Hofbauer B, et al. Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis [J]. Biochem Biophys Res Commun, 1998; 246(2)∶476.
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17.	Dobosz M, Hac S, Mionskowska L, et al. Organ microcirculatory disturbances in experimental acute pancreatitis. A role of nitric oxide [J]. Physiol Res, 2005; 54(4)∶363.
18.	Ranson JH, Rifkind KM, Roses DF, et al. Prognostic signs and the role of operative management in acute pancreatitis [J].Surg Gynecol Obstet, 1974; 139(1)∶69.
19.	Gloor B, Todd KE, Lane JS, et al. Hepatic Kupffer cell blockade reduces mortality of acute hemorrhagic pancreatitis in mice [J]. J Gastrointest Surg, 1998; 2(5)∶430.
20.	Pezzilli R, Billi P, Beltrandi E, et al. Impaired lymphocyte proliferation in human acute pancreatitis [J]. Digestion, 1997; 58(5)∶431.
21.	Demols A, Le Moine O, Desalle F, et al. CD4(+)T cells play an important role in acute experimental pancreatitis in mice [J].Gastroenterology, 2000; 118(3)∶582.
22.	Leindler L, Morschl E, Laszlo F, et al. Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats [J]. Pancreas, 2004; 29(2)∶157.
23.	Liu LR, Xia SH. Role of platelet-activating factor in the pathogenesis of acute pancreatitis [J]. World J Gastroenterol, 2006; 12(4)∶539.
24.	Warzecha Z, Dembinski A, Ceranowicz P, et al. IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis [J]. J Physiol Pharmacol, 2003; 54(4)∶575.
25.	Yoo BM, Yeo M, Oh TY, et al. Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling [J]. Pancreas, 2005; 30(3)∶e71.
26.	Kloppel G, Maillet B. The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis [J].Virchows Arch A Pathol Anat Histopathol, 1992; 420(1)∶1.
27.	Sarles H. Alcoholism and pancreatitis [J]. Scand J Gastroenterol, 1971； 6（3）∶193.
28.	Shimizu K, Kobayashi M, Tahara J, et al. Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells [J]. Gastroenterology, 2005; 128(7)∶2105.
29.	Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis [J]. Gut, 2002; 50(4)∶535.

1. 　Raraty MG, Connor S, Criddle DN, et al. Acute pancreatitis and organ failure: pathophysiology, natural history, and management strategies [J]. Curr Gastroenterol Rep, 2004; 6(2)∶99.
2. 　Gomez-Cambronero LG, Sabater L, Pereda J, et al. Role of cytokines and oxidative stress in the pathophysiology of acute pancreatitis: therapeutical implications [J]. Curr Drug Targets Inflamm Allergy, 2002; 1(4)∶393.
3. 　Pastor CM, Frossard JL. Are genetically modified mice useful for the understanding of acute pancreatitis? [J].FASEB J, 2001; 15(6)∶893.
4. 　Lerch MM, Saluja AK, Dawra R, et al. Acute necrotizing pancreatitis in the opossum: earliest morphological changes involve acinar cells [J]. Gastroenterology, 1992; 103(1)∶205.
5. 　Altavilla D, Famulari C, Passaniti M, et al. Attenuated cerulein-induced pancreatitis in nuclear factor-kappaB-deficient mice [J]. Lab Invest, 2003; 83(12)∶1723.
6. 　Hofbauer B, Saluja A, Lerch M, et al. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats [J]. Am J Physiol, 1998; 275(2 Pt 1)∶G352.
7. 　Steer ML, Meldolesi J, Figarella C. Pancreatitis. The role of lysosomes [J]. Dig Dis Sci, 1984; 29(10)∶934.
8. 　De Lisle RC. Altered posttranslational processing of glycoproteins in cerulein-induced pancreatitis [J]. Exp Cell Res, 2005; 308(1)∶101.
9. 　Halangk W, Lerch MM. Early events in acute pancreatitis [J].Clin Lab Med, 2005; 25(1)∶1.
10. 　Van Acker GJ, Saluja AK, Bhagat L, et al. Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity [J]. Am J Physiol Gastrointest Liver Physiol, 2002; 283(3)∶G794.
11. 　Saluja AK, Bhagat L, Lee HS, et al. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini [J]. Am J Physiol, 1999; 276(4 Pt 1)∶G835.
12. 　Krajewski E, Krajewski J, Spodnik JH, et al. Changes in the morphology of the acinar cells of the rat pancreas in the oedematous and necrotic types of experimental acute pancreatitis [J]. Folia Morphol (Warsz), 2005; 64(4)∶292.
13. 　Long J, Song N, Liu XP, et al. Nuclear factor-kappaB activation on the reactive oxygen species in acute necrotizing pancreatitic rats [J]. World J Gastroenterol, 2005; 11(27)∶4277.
14. 　Jeyarajah DR, Kielar M, Gokaslan ST, et al. Fas deficiency exacerbates cerulein-induced pancreatitis [J]. J Invest Surg, 2003; 16(6)∶325.
15. 　Bhatia M, Wallig MA, Hofbauer B, et al. Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis [J]. Biochem Biophys Res Commun, 1998; 246(2)∶476.
16. 　Satoh A, Gukovskaya AS, Edderkaoui M, et al. Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2 [J]. Gastroenterology, 2005; 129(2)∶639.
17. 　Dobosz M, Hac S, Mionskowska L, et al. Organ microcirculatory disturbances in experimental acute pancreatitis. A role of nitric oxide [J]. Physiol Res, 2005; 54(4)∶363.
18. 　Ranson JH, Rifkind KM, Roses DF, et al. Prognostic signs and the role of operative management in acute pancreatitis [J].Surg Gynecol Obstet, 1974; 139(1)∶69.
19. 　Gloor B, Todd KE, Lane JS, et al. Hepatic Kupffer cell blockade reduces mortality of acute hemorrhagic pancreatitis in mice [J]. J Gastrointest Surg, 1998; 2(5)∶430.
20. 　Pezzilli R, Billi P, Beltrandi E, et al. Impaired lymphocyte proliferation in human acute pancreatitis [J]. Digestion, 1997; 58(5)∶431.
21. 　Demols A, Le Moine O, Desalle F, et al. CD4(+)T cells play an important role in acute experimental pancreatitis in mice [J].Gastroenterology, 2000; 118(3)∶582.
22. 　Leindler L, Morschl E, Laszlo F, et al. Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats [J]. Pancreas, 2004; 29(2)∶157.
23. 　Liu LR, Xia SH. Role of platelet-activating factor in the pathogenesis of acute pancreatitis [J]. World J Gastroenterol, 2006; 12(4)∶539.
24. 　Warzecha Z, Dembinski A, Ceranowicz P, et al. IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis [J]. J Physiol Pharmacol, 2003; 54(4)∶575.
25. 　Yoo BM, Yeo M, Oh TY, et al. Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling [J]. Pancreas, 2005; 30(3)∶e71.
26. 　Kloppel G, Maillet B. The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis [J].Virchows Arch A Pathol Anat Histopathol, 1992; 420(1)∶1.
27. 　Sarles H. Alcoholism and pancreatitis [J]. Scand J Gastroenterol, 1971； 6（3）∶193.
28. 　Shimizu K, Kobayashi M, Tahara J, et al. Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells [J]. Gastroenterology, 2005; 128(7)∶2105.
29. 　Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis [J]. Gut, 2002; 50(4)∶535.

《中國普外基礎與臨床雜志》

急性胰腺炎發病機理的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

急性胰腺炎發病機理的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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Content

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