CD44v6在胃癌中的表達及其臨床意義_《中國普外基礎與臨床雜志》

作者：

徐勝軍 ¹ , 胡炳奎 ² , 凌志強 ³ , 趙挺 ⁴

1.浙江省上虞市中醫院外科（上虞312300）;;
2.上虞市中醫院檢驗科;;
3.浙江省醫科院（杭州310013）;;
4.浙江省人民醫院（杭州310014）;

關鍵詞：

胃癌 CD44v6 轉移預后

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目的研究胃癌組織中CD44v6的表達以及與腫瘤轉移和預后的關系。
方法應用流式細胞免疫技術對52例胃癌組織中CD44v6的表達進行檢測,分析CD44v6的表達與臨床病理特征的關系。
結果新鮮胃癌組織及距癌灶3 cm遠處的正常胃黏膜組織（經病理檢查證實）中CD44v6的表達陽性率分別為67.31%(35/52)和25.00（13/52），前者明顯高于后者（P＜0.01)。CD44v6的表達陽性率與胃癌浸潤深度、淋巴結轉移、遠處轉移及pTNM分期有關（P＜0.05）。
結論檢測胃癌組織中CD44v6的表達對判斷胃癌的浸潤、轉移及病期進展情況有一定的價值，CD44v6可作為一個預測胃癌轉移潛能和胃癌患者預后的病理生物學指標之一。

引用本文： 徐勝軍,胡炳奎,凌志強,趙挺. CD44v6在胃癌中的表達及其臨床意義. 中國普外基礎與臨床雜志, 2006, 13(1): 42-44. doi: 復制

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2.	Xin Y, Grace A, Gallagher MM, et al. CD44V6 in gastric carcinoma: a marker of tumor progression [Ｊ]. Appl Immunohistochem Mol Morphol, 2001; 9(2)∶138.
3.	Stachura J, Krzeszowiak A, Popiela T, et al. Preferential overexpression of CD44v5 in advanced gastric carcinoma Goseki grades Ⅰ and Ⅲ [Ｊ]. Pol J Pathol, 1999; 50(3)∶155.
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7.	Koyama S, Maruyama T, Adachi S. Expression of epidermal growth factor receptor and CD44 splicing variants sharing exons 6 and 9 on gastric and esophageal carcinomas: a twocolor flowcytometric analysis [Ｊ]. J Cancer Res Clin Oncol, 1999; 125(1)∶47.
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1. Yamaguchi A, Goi T, Yu J, et al. Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and longterm prognosis [Ｊ]. J Surg Oncol, 2002; 79(4)∶230.
2. Xin Y, Grace A, Gallagher MM, et al. CD44V6 in gastric carcinoma: a marker of tumor progression [Ｊ]. Appl Immunohistochem Mol Morphol, 2001; 9(2)∶138.
3. Stachura J, Krzeszowiak A, Popiela T, et al. Preferential overexpression of CD44v5 in advanced gastric carcinoma Goseki grades Ⅰ and Ⅲ [Ｊ]. Pol J Pathol, 1999; 50(3)∶155.
4. Van Driel M, Gunthert U, van Kessel AC, et al. CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells [Ｊ]. Leukemia, 2002; 16(1)∶135.
5. Gulmann C, Grace A, Leader M, et al. CD44v6: a potential marker of malignant transformation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays [Ｊ]. Eur J Gastroenterol Hepatol, 2003; 15(9)∶981.
6. Joo M, Lee HK, Kang YK. Expression of Ecadherin, betacatenin, CD44s and CD44v6 in gastric adenocarcinoma: relationship with lymph node metastasis [Ｊ]. Anticancer Res, 2003; 23(2B)∶1581.
7. Koyama S, Maruyama T, Adachi S. Expression of epidermal growth factor receptor and CD44 splicing variants sharing exons 6 and 9 on gastric and esophageal carcinomas: a twocolor flowcytometric analysis [Ｊ]. J Cancer Res Clin Oncol, 1999; 125(1)∶47.
8. Nakashio T, Narita T, Sato M, et al. The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer [Ｊ]. Anticancer Res, 1997; (1A)∶293.

《中國普外基礎與臨床雜志》

CD44v6在胃癌中的表達及其臨床意義

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《中國普外基礎與臨床雜志》

CD44v6在胃癌中的表達及其臨床意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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Content

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