p53及VEGF表達與結、直腸癌血道轉移發生的關系_《中國普外基礎與臨床雜志》

作者：

李繼坤 ¹ , 鄭淼 ¹ , 李遠芳 ² , 陳忠偉 ²

1.上海市第一人民醫院外科（上海200080）;;
2.復旦大學醫學院腫瘤醫院病理科（上海200032）;

關鍵詞：

結腸腫瘤直腸腫瘤轉移 p53蛋白血管內皮生長因子

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的研究p53及血管內皮細胞生長因子（vascular endothelial growth factor, VEGF）表達與結、直腸癌血道轉移發生的關系。方法應用免疫組織化學ABC法檢測79例結、直腸癌組織中p53及VEGF的表達。結果p53和VEGF在結、直腸癌組織中表達陽性率分別為48.1%和58.2%； 62.0%的病例中p53和VEGF表達一致。p53及VEGF表達與結、直腸癌靜脈侵犯、血道轉移密切相關（P＜0.05），p53及VEGF陽性表達組血道轉移發生率為66.7%，明顯高于p53及VEGF陰性表達組和p53陽性表達、VEGF陰性表達組（P＜0.01）； p53及VEGF陰性表達病例中，無同時性或異時性血道轉移發生。結論結合分析p53及VEGF表達狀態，對預測結、直腸癌血道轉移的發生有重要參考價值。

引用本文： 李繼坤,鄭淼,李遠芳,陳忠偉. p53及VEGF表達與結、直腸癌血道轉移發生的關系. 中國普外基礎與臨床雜志, 2002, 9(2): 112-114. doi: 復制

1.	Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma \[J\]. Cancer, 1996; 77(5)∶858.
2.	Takahashi Y, Bueana CD, Cleary KR, et al. p53, vessel count,and vascular endothelial growth factor expression in human colon cancer \[J\]. Int J Cancer,1998; 79(1)∶34.
3.	Yoshiji H, Gomez DE, Shibuya M, et al. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer \[J\]. Cancer Res, 1996; 56(9)∶2013.
4.	Porter PL, Gown AM. p53 expression in human malignant tumors \[J\]. Am J Pathol, 1992; 140(1)∶145.
5.	Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients \[J\]. Cancer Res, 1995; 55(22)∶5217.
6.	Yamamura T, Matsuzaki H, Suda T, et al. Clinicopathological variables and p53 overexpression as a combined prognosticator for hematogenic recurrence in colorectal cancer \[J\]. J Surg Oncol, 1999; 70(1)∶1.
7.	Kieser A, Weich HA, Brandner G, et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression \[J\]. Oncogene, 1994; 9(3)∶963.
8.	Steele RJC, Thompson AM, Hall PA, et al. The p53 tumour suppressor gene \[J\]. Br J Surg, 1998; 85(11)∶1460.

1. Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma \[J\]. Cancer, 1996; 77(5)∶858.
2. Takahashi Y, Bueana CD, Cleary KR, et al. p53, vessel count,and vascular endothelial growth factor expression in human colon cancer \[J\]. Int J Cancer,1998; 79(1)∶34.
3. Yoshiji H, Gomez DE, Shibuya M, et al. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer \[J\]. Cancer Res, 1996; 56(9)∶2013.
4. Porter PL, Gown AM. p53 expression in human malignant tumors \[J\]. Am J Pathol, 1992; 140(1)∶145.
5. Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients \[J\]. Cancer Res, 1995; 55(22)∶5217.
6. Yamamura T, Matsuzaki H, Suda T, et al. Clinicopathological variables and p53 overexpression as a combined prognosticator for hematogenic recurrence in colorectal cancer \[J\]. J Surg Oncol, 1999; 70(1)∶1.
7. Kieser A, Weich HA, Brandner G, et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression \[J\]. Oncogene, 1994; 9(3)∶963.
8. Steele RJC, Thompson AM, Hall PA, et al. The p53 tumour suppressor gene \[J\]. Br J Surg, 1998; 85(11)∶1460.

《中國普外基礎與臨床雜志》

p53及VEGF表達與結、直腸癌血道轉移發生的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

p53及VEGF表達與結、直腸癌血道轉移發生的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料