肛管直腸惡性黑色素瘤的診治進展_《中國普外基礎與臨床雜志》

作者：

王辛綜述 ¹ , 肖乾虎審校 ²

1.四川大學華西醫院腫瘤中心放療科（成都610041）;;
2.四川大學華西醫院普外科;

關鍵詞：

惡性黑色素瘤肛管直腸診斷治療

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的探討肛管直腸惡性黑色素瘤的診治進展。方法復習相關文獻并對本病病因、臨床特點、早期診斷、治療及預后作一綜述報告。結果肛管直腸惡性黑色素瘤是一種發病率很低的惡性腫瘤。發病原因可能與良性黑痣史，HIV感染，太陽光照射有關。主要癥狀有便血、局部腫塊、大便習慣改變等。早期診斷主要依賴對45~80歲的高危發病人群進行常規直腸檢查。CEA多克隆抗體標記陽性在病理診斷中有一定幫助。治療方法現存在爭議，多主張在手術治療（腹會陰聯合切除或局部廣泛切除）的基礎上輔以化療、放療或免疫治療。結論肛管直腸惡性黑色素瘤早期診斷困難，預后差，應提高警惕，最佳治療方法還有待進一步探討。

引用本文： 王辛綜述,肖乾虎審校. 肛管直腸惡性黑色素瘤的診治進展. 中國普外基礎與臨床雜志, 2002, 9(3): 210-212. doi: 復制

1.	Cagir B,Whiteford MH, Topham A，et al. Changingepidemiology of anorectal melanoma [J]. Dis Colon Rectum, 1999; 42(9)∶1203.
2.	Delikaris P,Koutmeridis D, Tsonis G,et al. Synchronous anorectal malignant melanoma and rectal adenocarcinoma: report of a case [J]. Dis Colon Rectum, 1997; 40(1)∶105.
3.	Weinstock MA.Epidemiology and prognosis of anorectal melanoma [J]. Gastroenterology, 1993; 104(1)∶174.
4.	Quinn D,Selah C.Malignant melanoma of the anus in a negro:report of a case and review of the literature [J].Dis Colon Rectum, 1977; 20（7）∶627.
5.	Slingluff CL Jr, Vollmer HF, Seigler HF. Anorectal melanoma: clinical characteristics and results of surgical management in twentyfour patients [J].Surgery,1990; 107(1)∶1.
6.	Ross M, Pezzi C,Pezzi T,et al. Patterns of failure in anorectal melanoma. A guide to surgical therapy [J]. Arch Surg, 1990; 125(3)∶313.
7.	Goldman S,Glimelius B,Pahlman L.Anorectal malignant melanoma in Sweeden: report of patients [J].Dis Colon Rectum,1990; 33（10）∶874.
8.	Ben IO, Levy R, Weill S,et al.Anorectal malignant melanoma.A clinicopathologic study including immunohistochemistry and DNA flow cytometry [J]. Cancer, 1997; 79(1)∶18.
9.	Vijayaraghavan M,Kharbanda K, Mathur M. S100 staining for the diagnosis of melanoma of the anal canal [J]. Indian J Pathol Microbiol, 1992; 35(2)∶113.
10.	Wanebo HJ,Woodruff JM,Farr GH,et al.Anorextal melanoma [J].Cancer,1981; 47（7）∶1891.
11.	Thibault C, Sagar P, Nivatvongs S, et al. Anorectal melanomaan incurable disease [J]?Dis Colon Rectum, 1997; 40(6)∶661.
12.	Whooley BP,Shaw P, Astrow AB, et al.Long term survival after locally aggressive anorectal melanoma [J]. Am Surg, 1998; 64(3)∶245.
13.	Vorpahl U, Jager E,Schmidbauer U, et al.Value of inguinal lymph node excision in anorectal melanoma [J]. Zentralbl Chir, 1996; 121(6)∶483.
14.	Brady MS, Kavolius JP,Quan SH. Anorectal melanoma. A 64year experience at Memorial Sloan Kettering Cancer Center [J]. Dis Colon Rectum, 1995; 38(2)∶146.
15.	Turk PS, Belliveau JF, Darnowski JW,et al.Isolated pelvic perfusion for unresectable cancer using a balloon occlusion technique [J]. Arch Surg, 1993; 128(5)∶533.
16.	Wanebo HJ, Chung MA, Levy AIM,et al.Preoperative therapy for advanced pelvic malignancy by isolated pelvic perfusion with the balloon occlusion technique [J].Ann Surg Oncol, 1996; 3(3)∶295.
17.	Melhouf MM, el Amrani N, Mathieu DH,et al. Anorectal malignant melanomas. Apropos of 5 cases. Review of the literature[J]. Ann Gastroenterol Hepatol Paris,1995; 31(4)∶209.
18.	Cooper PH,Mills SE,Alien S.Malignant melanoma of the anas: report of 12 patients and analysis of 255 additional cases [J].Dis Colon Recum,1982; 25（7）∶693.

1. Cagir B,Whiteford MH, Topham A，et al. Changingepidemiology of anorectal melanoma [J]. Dis Colon Rectum, 1999; 42(9)∶1203.
2. Delikaris P,Koutmeridis D, Tsonis G,et al. Synchronous anorectal malignant melanoma and rectal adenocarcinoma: report of a case [J]. Dis Colon Rectum, 1997; 40(1)∶105.
3. Weinstock MA.Epidemiology and prognosis of anorectal melanoma [J]. Gastroenterology, 1993; 104(1)∶174.
4. Quinn D,Selah C.Malignant melanoma of the anus in a negro:report of a case and review of the literature [J].Dis Colon Rectum, 1977; 20（7）∶627.
5. Slingluff CL Jr, Vollmer HF, Seigler HF. Anorectal melanoma: clinical characteristics and results of surgical management in twentyfour patients [J].Surgery,1990; 107(1)∶1.
6. Ross M, Pezzi C,Pezzi T,et al. Patterns of failure in anorectal melanoma. A guide to surgical therapy [J]. Arch Surg, 1990; 125(3)∶313.
7. Goldman S,Glimelius B,Pahlman L.Anorectal malignant melanoma in Sweeden: report of patients [J].Dis Colon Rectum,1990; 33（10）∶874.
8. Ben IO, Levy R, Weill S,et al.Anorectal malignant melanoma.A clinicopathologic study including immunohistochemistry and DNA flow cytometry [J]. Cancer, 1997; 79(1)∶18.
9. Vijayaraghavan M,Kharbanda K, Mathur M. S100 staining for the diagnosis of melanoma of the anal canal [J]. Indian J Pathol Microbiol, 1992; 35(2)∶113.
10. Wanebo HJ,Woodruff JM,Farr GH,et al.Anorextal melanoma [J].Cancer,1981; 47（7）∶1891.
11. Thibault C, Sagar P, Nivatvongs S, et al. Anorectal melanomaan incurable disease [J]?Dis Colon Rectum, 1997; 40(6)∶661.
12. Whooley BP,Shaw P, Astrow AB, et al.Long term survival after locally aggressive anorectal melanoma [J]. Am Surg, 1998; 64(3)∶245.
13. Vorpahl U, Jager E,Schmidbauer U, et al.Value of inguinal lymph node excision in anorectal melanoma [J]. Zentralbl Chir, 1996; 121(6)∶483.
14. Brady MS, Kavolius JP,Quan SH. Anorectal melanoma. A 64year experience at Memorial Sloan Kettering Cancer Center [J]. Dis Colon Rectum, 1995; 38(2)∶146.
15. Turk PS, Belliveau JF, Darnowski JW,et al.Isolated pelvic perfusion for unresectable cancer using a balloon occlusion technique [J]. Arch Surg, 1993; 128(5)∶533.
16. Wanebo HJ, Chung MA, Levy AIM,et al.Preoperative therapy for advanced pelvic malignancy by isolated pelvic perfusion with the balloon occlusion technique [J].Ann Surg Oncol, 1996; 3(3)∶295.
17. Melhouf MM, el Amrani N, Mathieu DH,et al. Anorectal malignant melanomas. Apropos of 5 cases. Review of the literature[J]. Ann Gastroenterol Hepatol Paris,1995; 31(4)∶209.
18. Cooper PH,Mills SE,Alien S.Malignant melanoma of the anas: report of 12 patients and analysis of 255 additional cases [J].Dis Colon Recum,1982; 25（7）∶693.

《中國普外基礎與臨床雜志》

肛管直腸惡性黑色素瘤的診治進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

肛管直腸惡性黑色素瘤的診治進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料