射頻消融治療大肝癌的安全性和近期療效△_《中國普外基礎與臨床雜志》

作者：

第三軍醫大學西南肝膽外科醫院，全軍肝膽外科研究所（重慶400038）;

關鍵詞：

射頻消融治療大肝癌

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目的探討射頻消融（RFA）治療大肝癌的安全性和療效。方法采用可擴張的集束電極對不能耐受或無法手術切除的大肝癌患者進行RFA治療。本組共治療大肝癌患者43例，腫瘤直徑5～10 cm，平均7.5 cm，其中8例于RFA治療前曾行1～2次肝動脈栓塞化療（TAE），治療前、后檢查肝功、增強CT掃描、彩超以及細針肝穿活檢，觀察RFA治療時間、次數和住院時間，RFA治療后的并發癥以及腫瘤完全壞死率，并隨訪患者的生存情況。結果43例患者共行RFA治療67次，每例1～3次，平均1.6次；每次治療時間為55～150 min，平均75 min；住院時間3～15 d，平均8.7 d。RFA治療的主要并發癥包括電極板局部皮膚燒傷2例（4.7%），中到大量的胸腔積液3例（7.0%），總的發生率為11.6%； RFA治療后6個月以上的CT復查，腫瘤完全壞死率為41.0%，AFP陽性的31例患者在RFA治療后6～12個月內有3例轉陰，5例明顯下降。43例中有39例經12～18個月的隨訪，其1年生存率為69.2%。結論RFA對大肝癌的治療是一種微創、安全有效的方法。

引用本文： 范林軍,馬寬生,何振平,黃小蘭,陳敏,董家鴻. 射頻消融治療大肝癌的安全性和近期療效△. 中國普外基礎與臨床雜志, 2002, 9(4): 265-268. doi: 復制

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2. 黃志強主編.現代腹部外科學 [M].第1版.長沙: 湖南科學技術出版社，1995∶249~271.
3. Livraghi T, Goldberg SN, Lazzaroni S, et al. Hepatocellular carcinoma: radiofrequency ablation of medium and large lesions [J]. Radiology, 2000; 214(3)∶761.
4. Livraghi T, Goldberg SN, Lazzaroni S,et al. Small hepatocellular carcinoma: treatment with radiofrequency ablation versus ethanol injection [J]. Radiology, 1999; 210(3)∶655.
5. Buscarini L, Buscarini E, Di Stasi M,et al. Percutaneous radiofrequency thermal ablation combined with transcatheter arterial embolization in the treatment of large hepatocellular carcinoma [J].Ultraschall Med,1999; 20(2)∶47.
6. Seegenschmiedt MH, Brady LW, Sauer R. Interstitial thermoradiotherapy: review on technical and clinical aspects [J].Am J Clin Oncol,1990; 13(4)∶352.
7. Rossi S, Garbagnati F, De Francesco I, et al. Relationship between the shape and size of radiofrequency induced thermal lesions and hepatic vascularization [J]. Tumori,1999; 85(2)∶128.
8. 徐輝雄，張青萍. 超聲引導下肝臟腫瘤的射頻消融治療 [J].中華超聲影像學雜志,2000； 9（4）∶255.
9. Seki T, Tamai T, Nakagawa T,et al. Percutaneous radiofrequency (RF) ablation therapy for hepatocellular carcinoma: difficulty in removing the expandable RF needle electrode [J].AJR Am J Roentgenol,2000; 174(1)∶264.
10. Farmer DG, Rosove MH, Shaked A, et al. Current treatment modalities for hepatocellular carcinoma [J]. Ann Surg,1994; 219(3)∶236.
11. Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignmancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance [J]. AJR Am J Roentgenol, 2000; 174(2)∶323.

《中國普外基礎與臨床雜志》

射頻消融治療大肝癌的安全性和近期療效△

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《中國普外基礎與臨床雜志》

射頻消融治療大肝癌的安全性和近期療效△

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料