運用RIA法對76例男性肝癌及10例女性肝癌患者血清睪丸酮(T)、雌二醇(E2)及孕酮(P)水平進行測定。結果:男性肝癌手術組及非手術組血清T水平顯著高于肝良性病變組及正常對照組,E2水平則顯著低于后兩組;雄/雌激素比例(T/E2)顯著高于后兩組;肝癌切除后T水平下降,E2水平升高,T/E2比值下降,與肝良性病變組及正常對照組比較無顯著差異。女性肝癌組T、E2水平與肝良性病變組及正常對照組比較無顯著差異,但T/E2比例明顯高于正常對照組。男、女肝癌組的P水平均未見明顯改變。本組資料結果提示:高T水平及低E2水平與肝癌有關,性激素比例失調在肝癌的發生和發展中起了重要作用。
引用本文:
肖開銀,李紹森,盧全書. 性激素與原發性肝癌. 中國普外基礎與臨床雜志, 1998, 5(4): 214-216. doi:
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- 1. Baum IK, Bookstein JJ, Holtz F, et al. Possible association between benign hepatomas and oral contraceptives. Lancet, 1973; ii(7835)∶926.
- 2. 蔣國禎,徐冠南,李先興.影響女性肝細胞癌預后因素的初步探討.現代外科,1997; 3(4)∶6.
- 3. Yu MW, Cheng CJ. Elevated serm testosterone levels and risk of hepatocellular carcinoma. Cancer Res, 1993; 53(4)∶790.
- 4. Farinati F, Demaria N, Chiarmonte M, et al.Hormone treatment of hepatocellular carcinoma. J Hepato, 1991; 12(3)∶402.