多發性肌炎/皮肌炎相關的間質性肺疾病急性加重的研究進展_《中國呼吸與危重監護雜志》

作者：

郝秀 , 李振華

中國醫科大學附屬第一醫院呼吸疾病研究所（遼寧沈陽 110001）;

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結締組織病相關的間質性肺疾病的死亡率高, 在美國每年約有1600 人死于結締組織病相關的間質性肺疾病, 約占所有間質性肺疾病死亡人數的25% [ 1] , 死因多為間質性肺疾病的急性加重, 而多發性肌炎/皮肌炎( polymyositis/ dermatomyositis, PM/DM) 是結締組織病中合并肺間質疾病發病率較高的類型, 且最容易發生間質性肺疾病的急性加重[ 2] 。PM/DM可分為多發性肌炎、典型的皮肌炎、無肌病性皮肌炎( CADM) 。間質性肺疾病可發生于多發性肌炎/ 皮肌炎之前、之中或之后, 且無肌病性皮肌炎的表現無特異性, 故多發性肌炎/ 皮肌炎相關的間質性肺疾病( PM/DM-ILD) 急性加重病死率極高[ 3] 。本文將對PM/DM-ILD 急性加重的相關進展進行綜述。

引用本文： 郝秀,李振華. 多發性肌炎/皮肌炎相關的間質性肺疾病急性加重的研究進展. 中國呼吸與危重監護雜志, 2009, 09(5): 509-511. doi: 復制

1.	馮瑞娥, 劉鴻瑞. 結締組織疾病相關的肺間質性疾病. 見: 中華醫學會第二屆全國彌漫性間質性肺病及風濕免疫性疾病肺損傷學術會議論文匯編. 桂林.
2.	張恒, 董怡, 張奉春. 結締組織病肺間質病變的臨床特點分析. 中華風濕病雜志, 1999, 3: 247-248.
3.	Marie I, Hachulla E, Ch　rin P, et al. Interstitial lung disease in polymyositis and dermatomyositis. Arthritis and rheumatism, 2002 , 47: 614-622.
4.	Fathi M, Lundberg IE. Interstitial lung disease in polymyositis and dermatomyositis. Curr Opin Rheumatol, 2005, 17: 701-706.
5.	Ye S, Chen XX, Lu XY, et al. Adult clinically amyopathic dermatomyositis with rapid progressive interstitial lung disease: a retrospective cohort study. Clin Rheumato, 2007, 26: 1647-1654.
6.	Fathi M, Dastmalchi M, Rasmussen E, et al. Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis. Ann Rheum Dis, 2004, 63: 297-301.
7.	Parambil JG, Myer JL, Ryu JH. Diffuse alveolar damage: uncommon manifestation of pulmonary involvement in patients with connective tissue diseases. Chest, 2006, 130: 553-558.
8.	Kameda H, Nagasawa H, Oqawa H, et al. Combination therapy with corticosteroids, cyclosporine A, and intravenous pulse cyclophosphamide for acute/ subacute interstitial pneumonia in patients with dermatomyositis. J Rheumatol, 2005, 32: 1719-1726.
9.	Hayashi S, Tanaka M, Kobayashi H, et al. High-resolution computed tomography characterization of interstitial lung diseases in polymyositis / dermatomyositis. J Rheumatol, 2008 , 35: 260 -269.
10.	Hideto K, Tsutomu T. Recent advances in the treatment of interstitial lung disease in patients with polymyositis / dermatomyositis. Endocr metab immune disord drug targets, 2006 , 6: 409-415.
11.	Collard HR, Moore BB, Flaherty KR, et al. Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care, 2007, 176: 636-643.
12.	侯巖峰, 張源潮. 皮肌炎并發肺間質病變. 中國實用內科雜志, 2005, 25: 558.
13.	Mastaglia FL. Inflammatory muscle diseases. Neurol India, 2008 , 56: 263-270.
14.	Southeimer RD, Miyagawa S. Potentially fatal interstitial lung disease can occur in clinically amyopathic dermatomyositis. J Am Acad Dermatol, 2003, 48: 797-798.
15.	田欣倫, 許文兵, 施舉紅, 等. 普通型間質性肺炎與非特異性間質性肺炎急性加重的臨床與病理表現. 中華結核和呼吸雜志, 2008, 31: 255-259.
16.	佟勝全, 史旭華, 蘇金梅, 等. 多發性肌炎/ 皮肌炎合并縱隔氣腫的臨床分析. 中華醫學雜志, 2006, 86: 624-627.
17.	Fujita J, Ohtsuki Y, Yoshinouchi T, et al. Idiopathic non-specific interstitial pneumonia: as an “autoimmune interstitial pneumonia”. Respir Med, 2005, 99: 234-240.
18.	Sato T, Fujita J, Yamadori I, et al. Non-specific interstitial pneumonia; as the first clinical presentation of various collagen vascular disorders. Rheumatol Int, 2006, 26: 551-555.
19.	Bohan A, Peter JB. Polymyositis and dermatomyositis. N Engl J Med, 1985, 292: 403-407.
20.	Takada K, Nagasaka K, Miyasaka N. Polymyositis/ dermatomyositis and interstitial lung disease: a new therapeutic approach with T-cellspecific immunosuppressants. Autoimmunity, 2005 , 38: 383 -392.
21.	Saito E, Koike T, Hashimoto H, et al. Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis . Mod Rheumatol, 2008, 18: 34-44.
22.	Danieli MG, Calcabrini L, Marchetti A, et al. Intravenous immunoglobulin treatment autoimmune diseases. Recenti Prog Med, 2007, 98: 322-326.
23.	Kotani T, Makino S, Takeuchi T, et al. Early intervention with corticosteroids and cyclosporine A and 2-hour postdose blood concentration monitoring improves the prognosis of acute/ subacute interstitial pneumonia in dermatomyositis. J Rheumatol, 2008, 35 : 254-259.
24.	Falagas ME, Manta KG, Betsi GI, et al. Infection-related morbidity and mortality in patients with connective tissue diseases: a systematic review. Clin Rheumatol, 2007 , 26: 663 -670.
25.	, 24-25.

1. 馮瑞娥, 劉鴻瑞. 結締組織疾病相關的肺間質性疾病. 見: 中華醫學會第二屆全國彌漫性間質性肺病及風濕免疫性疾病肺損傷學術會議論文匯編. 桂林.
2. 張恒, 董怡, 張奉春. 結締組織病肺間質病變的臨床特點分析. 中華風濕病雜志, 1999, 3: 247-248.
3. Marie I, Hachulla E, Ch　rin P, et al. Interstitial lung disease in polymyositis and dermatomyositis. Arthritis and rheumatism, 2002 , 47: 614-622.
4. Fathi M, Lundberg IE. Interstitial lung disease in polymyositis and dermatomyositis. Curr Opin Rheumatol, 2005, 17: 701-706.
5. Ye S, Chen XX, Lu XY, et al. Adult clinically amyopathic dermatomyositis with rapid progressive interstitial lung disease: a retrospective cohort study. Clin Rheumato, 2007, 26: 1647-1654.
6. Fathi M, Dastmalchi M, Rasmussen E, et al. Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis. Ann Rheum Dis, 2004, 63: 297-301.
7. Parambil JG, Myer JL, Ryu JH. Diffuse alveolar damage: uncommon manifestation of pulmonary involvement in patients with connective tissue diseases. Chest, 2006, 130: 553-558.
8. Kameda H, Nagasawa H, Oqawa H, et al. Combination therapy with corticosteroids, cyclosporine A, and intravenous pulse cyclophosphamide for acute/ subacute interstitial pneumonia in patients with dermatomyositis. J Rheumatol, 2005, 32: 1719-1726.
9. Hayashi S, Tanaka M, Kobayashi H, et al. High-resolution computed tomography characterization of interstitial lung diseases in polymyositis / dermatomyositis. J Rheumatol, 2008 , 35: 260 -269.
10. Hideto K, Tsutomu T. Recent advances in the treatment of interstitial lung disease in patients with polymyositis / dermatomyositis. Endocr metab immune disord drug targets, 2006 , 6: 409-415.
11. Collard HR, Moore BB, Flaherty KR, et al. Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care, 2007, 176: 636-643.
12. 侯巖峰, 張源潮. 皮肌炎并發肺間質病變. 中國實用內科雜志, 2005, 25: 558.
13. Mastaglia FL. Inflammatory muscle diseases. Neurol India, 2008 , 56: 263-270.
14. Southeimer RD, Miyagawa S. Potentially fatal interstitial lung disease can occur in clinically amyopathic dermatomyositis. J Am Acad Dermatol, 2003, 48: 797-798.
15. 田欣倫, 許文兵, 施舉紅, 等. 普通型間質性肺炎與非特異性間質性肺炎急性加重的臨床與病理表現. 中華結核和呼吸雜志, 2008, 31: 255-259.
16. 佟勝全, 史旭華, 蘇金梅, 等. 多發性肌炎/ 皮肌炎合并縱隔氣腫的臨床分析. 中華醫學雜志, 2006, 86: 624-627.
17. Fujita J, Ohtsuki Y, Yoshinouchi T, et al. Idiopathic non-specific interstitial pneumonia: as an “autoimmune interstitial pneumonia”. Respir Med, 2005, 99: 234-240.
18. Sato T, Fujita J, Yamadori I, et al. Non-specific interstitial pneumonia; as the first clinical presentation of various collagen vascular disorders. Rheumatol Int, 2006, 26: 551-555.
19. Bohan A, Peter JB. Polymyositis and dermatomyositis. N Engl J Med, 1985, 292: 403-407.
20. Takada K, Nagasaka K, Miyasaka N. Polymyositis/ dermatomyositis and interstitial lung disease: a new therapeutic approach with T-cellspecific immunosuppressants. Autoimmunity, 2005 , 38: 383 -392.
21. Saito E, Koike T, Hashimoto H, et al. Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis . Mod Rheumatol, 2008, 18: 34-44.
22. Danieli MG, Calcabrini L, Marchetti A, et al. Intravenous immunoglobulin treatment autoimmune diseases. Recenti Prog Med, 2007, 98: 322-326.
23. Kotani T, Makino S, Takeuchi T, et al. Early intervention with corticosteroids and cyclosporine A and 2-hour postdose blood concentration monitoring improves the prognosis of acute/ subacute interstitial pneumonia in dermatomyositis. J Rheumatol, 2008, 35 : 254-259.
24. Falagas ME, Manta KG, Betsi GI, et al. Infection-related morbidity and mortality in patients with connective tissue diseases: a systematic review. Clin Rheumatol, 2007 , 26: 663 -670.
25. , 24-25.

《中國呼吸與危重監護雜志》

多發性肌炎/皮肌炎相關的間質性肺疾病急性加重的研究進展

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《中國呼吸與危重監護雜志》

多發性肌炎/皮肌炎相關的間質性肺疾病急性加重的研究進展

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