支氣管哮喘患者血清中8-異前列腺素水平研究_《中國呼吸與危重監護雜志》

作者：

李永霞 , 陳敏 , 鐘紅 , 海冰

昆明醫學院第二附屬醫院呼吸內科( 云南昆明 650101) 通訊作者: 鐘紅, E-mail: liyongxia@ hotmail. com;

關鍵詞：

哮喘 8-異前列腺素

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目的探討支氣管哮喘患者血清中8-異前列腺素( 8-iso-PG) 水平檢測的臨床意義。方法選取2009 年2 月至8 月就診于昆明醫學院第二附屬醫院呼吸內科的18 例哮喘急性發作期患者為哮喘組, 經治療后達緩解期。選取2009 年8 月來自昆明醫學院第二附屬醫院的職工體檢志愿者20 例為健康對照組。測定所有研究對象血清中8-iso-PG 水平及肺功能指標FEV1% pred。結果哮喘患者急性發作期血清中8-iso-PG 水平均高于緩解期和健康對照組[ ( 157. 46 ±46. 99) pg/mL 比( 43. 52 ±13. 62) pg/mL和( 15. 23 ±1. 96) pg/mL, P lt;0. 01] , 緩解期哮喘患者血清中8-iso-PG 水平也高于健康對照組( P lt;0. 01) 。哮喘患者急性發作期血清中8-iso-PG 水平與FEV1% pred 呈負相關( r =- 0. 533, P lt;0. 05) 。結論 8-iso-PG 作為氧化應激反應的標記物參與了哮喘的發病, 通過監測其在哮喘患者血清中的水平可以反映哮喘患者體內氧化應激反應狀態, 可以作為一種評估哮喘患者病情嚴重程度及隨訪治療效果的指標。

引用本文： 李永霞,陳敏,鐘紅,海冰. 支氣管哮喘患者血清中8-異前列腺素水平研究. 中國呼吸與危重監護雜志, 2010, 9(6): 598-601. doi: 復制

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10.	Li Yongxia, Chongsuvivatwong V, Geater A, et al. Are biomarker levels a good follow-up tool for evaluating obstructive sleep apnea syndrome treatments? Respiration, 2008, 76: 317-323 .
11.	Li Yongxia, Chongsuvivatwong V, Geater A, et al. Exhaled breath condensate cytokine level as a diagnostic tool for obstructive sleep apnea syndrome. Sleep Med, 2009, 10: 95 -103.
12.	Zhao JJ, Shimizu Y, Dobashi K, et al. The Relationship Between Oxidative Stress and Acid Stress in Adult Patients With Mild Asthma. J Investing Clin Immunol, 2008 , 18: 41-45.
13.	Montuschi P, Barnes PJ. Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol, 2002, 109 : 615-620.
14.	劉翱, 李少瑩, 楊偉康, 等. 支氣管哮喘患者呼出氣冷凝液中8 -異前列腺素的研究. 中國呼吸與危重監護雜志, 2009 , 8, 337 -340.

1. Montuschi P, Kharitonov SA, Ciabattoni G, et al. Exhaled 8 -isoprostane as a new non-invasive biomarker of oxidative stress in Cystic fibrosis. Thorax, 2000, 55: 205-209.
2. Janssen LJ. Isoprostanes: an overview and putative roles in pulmonary pathophysiology. Am J Physiol Lung Cell Mol Physiol,2001, 280: L1067 -L1082.
3. 中華醫學會呼吸病學分會哮喘學組. 支氣管哮喘防治指南( 支氣管哮喘的定義、診斷、治療和管理方案) . 中華結核和呼吸雜志, 2008, 31: 177-185.
4. Montuschi P, Barnes PJ, Roberts LJ 2nd, et al. Isoprostane: markers and mediators of oxidative stress. FASEB J, 2004, 18: 1791 -1800 .
5. Helmersson J, Basu S. F2-isoprostane excretion rate and diurnal variation in human urine. Prostaglandins Leukot Essent Fatty Acids,2004, 61: 203.
6. Kirschvink N, Martin N, Fievez L, et al. Airway inflammation in cadmium exposed rats is associated with pulmonary oxidative stress and emphysema. Free Radical Research, 2006, 40 : 241-250 .
7. Caramori G, Papi A. Oxidants and asthma. Thorax, 2004, 59: 170 -173 .
8. Nadeem A, Raj HG, Chhabra SK. Increased oxidative stress in acute exacerbations of asthma. J Asthma, 2005 , 42: 42-45.
9. 于進洪, 李軍濤, 李國翔, 等. COPD 急性加重期患者血清8 -isoprostane 水平與肺功能和動脈氧分壓的關系. 山東醫藥,2008, 48: 64-65 .
10. Li Yongxia, Chongsuvivatwong V, Geater A, et al. Are biomarker levels a good follow-up tool for evaluating obstructive sleep apnea syndrome treatments? Respiration, 2008, 76: 317-323 .
11. Li Yongxia, Chongsuvivatwong V, Geater A, et al. Exhaled breath condensate cytokine level as a diagnostic tool for obstructive sleep apnea syndrome. Sleep Med, 2009, 10: 95 -103.
12. Zhao JJ, Shimizu Y, Dobashi K, et al. The Relationship Between Oxidative Stress and Acid Stress in Adult Patients With Mild Asthma. J Investing Clin Immunol, 2008 , 18: 41-45.
13. Montuschi P, Barnes PJ. Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol, 2002, 109 : 615-620.
14. 劉翱, 李少瑩, 楊偉康, 等. 支氣管哮喘患者呼出氣冷凝液中8 -異前列腺素的研究. 中國呼吸與危重監護雜志, 2009 , 8, 337 -340.

《中國呼吸與危重監護雜志》

支氣管哮喘患者血清中8-異前列腺素水平研究

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《中國呼吸與危重監護雜志》

支氣管哮喘患者血清中8-異前列腺素水平研究

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料