聚乙二醇滴眼液對準分子激光上皮下角膜磨鑲術后角膜霧狀混濁形成的影響_《華西醫學》

作者：

譚業雙 , 周霞 , 孫斌 , 潘桂萍

湖北醫藥學院附屬太和醫院眼科（湖北十堰，442000）;

關鍵詞：

準分子激光上皮下角膜磨鑲術聚乙二醇滴眼液角膜霧狀混濁

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目的　探討聚乙二醇滴眼液對準分子激光上皮下角膜磨鑲術（LASEK）后角膜霧狀混濁（haze）影響的臨床研究。方法　回顧性分析2009年3月－2010年3月行LASEK的患者45例90只眼的臨床資料。患者屈光度（?4.68 ± 2.30）D（?1.75～?6.50 D），隨機分為聚乙二醇滴眼液組（試驗組）和對照組，術后定期隨訪觀察兩組角膜haze形成、角膜上皮愈合時間、視力恢復情況及屈光度。結果　術后1、3、6個月，兩組haze形成差異無統計學意義（P＞0.05），試驗組術后第1、3、5天角膜刺激癥狀明顯輕于對照組（P＜0.05），上皮愈合速度較對照組更快（P＜0.05）。結論　LASEK術后應用聚乙二醇滴眼液雖然能減輕術后患者角膜刺激癥狀,能促進角膜上皮更快愈合，但是不能減輕haze的形成。

引用本文： 譚業雙,周霞,孫斌,潘桂萍. 聚乙二醇滴眼液對準分子激光上皮下角膜磨鑲術后角膜霧狀混濁形成的影響. 華西醫學, 2012, 27(4): 567-569. doi: 復制

1.	Kornilovsky IM. Clinical results after subepithelial photorefractive keratectomy (LASEK)[J]. J Refract Surg, 2001, 17(2): 222-223.
2.	Lee JB , Seong GJ , Lee J H , et al. Comparison of laser epithelial keratomileusis and photorefractive keratectomy for low to moderate myopia[J]. J Cataract Refract Surg, 2001, 27(4): 565-570.
3.	譚業雙, 劉磊, 李新宇. LASEK術后Haze的發病機制與防治的研究進展[J].眼科新進展, 2007, 27(7): 546-548.
4.	趙家良, 黎曉新, 董冬生, 等. 普拉洛芬滴眼液治療白內障術后炎癥和非感染性眼前段炎癥的臨床評價[J]. 眼科研究, 2000, 18(6): 560-564.
5.	Fantes FE, Hanna KD, Waring GO, et al. Wound healing afterexcimer laser keratomileusis (photorefractive keratectomy) in monkeys[J]. Arch Ophthalmol, 1990, 108(5): 665-675.
6.	Camellin M.LASEK may after the advantages of both lasik and PRK[J]. Ocu Surg N Int， 1999, 10(3): 14-15 .
7.	Scerrati E. Laser in situ keratomileusis vs laser epithelial keratomileusis (LASIK vs LASEK) [J]. J RefractSurg, 2001, 17(2): 219-221.
8.	Hersh PS, Stulting RD, Steinert RF, et al. Results of Phase Ⅲexcimer laser photorefractive keratectomy for myopia; the Summit PRK Study Group[J]. Ophthalmology, 1997, 104(10): 1535-1553.
9.	Kremer I, Kaplan A, Novikov I, et al. Patterns of late corneal scarring after photorefractive keratectomy in high and severe myopia[J]. Ophthalmology, 1999, 106(3): 467-473.
10.	Cua IY, Pepose JS. Late corneal scarring after photorefractive keratectomy concurrent with the development of systemic lupus erythematosus[J]. J Refract Surg, 2002, 18(6): 750-752.
11.	Stojanovic A, Nitter TA. Correlation between ultraviolet radiation level and the incidence of late-onset corneal haze after photorefractive keratectomy[J]. J Cataract Refract Surg, 2001, 27(3): 404-410.
12.	Mocanu C, Bǎrǎscu D, B rjovanu F, et al. Assessment of systane in severe dry eye[J]. Oftalmologia, 2008, 52(1): 105-110.
13.	Gifford P, Evans BJ, Morris J. A clinical evaluation of Systane[J]. Cont Lens Anterior Eye, 2006, 29(1): 31-40.
14.	David K. A two-week clinical evaluation of the safety of systane ultra in contact lens-wearing patients [J]. Clin Ophthalmol, 2010, 4(2): 27-32.
15.	Wang MX, Gray TB, Clan PW, et al. Reduction in corneal haze apoptosis by amniotic membrane matrix in excimer laser photo ablation in rabbits[J]. J Caratact Refract Surg, 2001, 27(2): 310 -319.
16.	Netto MV, Mohan RR, Ambrósio R Jr, et al.Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy[J]. Cornea, 2005, 24(5): 509-522.

1. 　Kornilovsky IM. Clinical results after subepithelial photorefractive keratectomy (LASEK)[J]. J Refract Surg, 2001, 17(2): 222-223.
2. 　Lee JB , Seong GJ , Lee J H , et al. Comparison of laser epithelial keratomileusis and photorefractive keratectomy for low to moderate myopia[J]. J Cataract Refract Surg, 2001, 27(4): 565-570.
3. 　譚業雙, 劉磊, 李新宇. LASEK術后Haze的發病機制與防治的研究進展[J].眼科新進展, 2007, 27(7): 546-548.
4. 　趙家良, 黎曉新, 董冬生, 等. 普拉洛芬滴眼液治療白內障術后炎癥和非感染性眼前段炎癥的臨床評價[J]. 眼科研究, 2000, 18(6): 560-564.
5. 　Fantes FE, Hanna KD, Waring GO, et al. Wound healing afterexcimer laser keratomileusis (photorefractive keratectomy) in monkeys[J]. Arch Ophthalmol, 1990, 108(5): 665-675.
6. 　Camellin M.LASEK may after the advantages of both lasik and PRK[J]. Ocu Surg N Int， 1999, 10(3): 14-15 .
7. 　Scerrati E. Laser in situ keratomileusis vs laser epithelial keratomileusis (LASIK vs LASEK) [J]. J RefractSurg, 2001, 17(2): 219-221.
8. 　Hersh PS, Stulting RD, Steinert RF, et al. Results of Phase Ⅲexcimer laser photorefractive keratectomy for myopia; the Summit PRK Study Group[J]. Ophthalmology, 1997, 104(10): 1535-1553.
9. 　 Kremer I, Kaplan A, Novikov I, et al. Patterns of late corneal scarring after photorefractive keratectomy in high and severe myopia[J]. Ophthalmology, 1999, 106(3): 467-473.
10. 　Cua IY, Pepose JS. Late corneal scarring after photorefractive keratectomy concurrent with the development of systemic lupus erythematosus[J]. J Refract Surg, 2002, 18(6): 750-752.
11. 　Stojanovic A, Nitter TA. Correlation between ultraviolet radiation level and the incidence of late-onset corneal haze after photorefractive keratectomy[J]. J Cataract Refract Surg, 2001, 27(3): 404-410.
12. 　Mocanu C, Bǎrǎscu D, B rjovanu F, et al. Assessment of systane in severe dry eye[J]. Oftalmologia, 2008, 52(1): 105-110.
13. 　Gifford P, Evans BJ, Morris J. A clinical evaluation of Systane[J]. Cont Lens Anterior Eye, 2006, 29(1): 31-40.
14. 　David K. A two-week clinical evaluation of the safety of systane ultra in contact lens-wearing patients [J]. Clin Ophthalmol, 2010, 4(2): 27-32.
15. 　Wang MX, Gray TB, Clan PW, et al. Reduction in corneal haze apoptosis by amniotic membrane matrix in excimer laser photo ablation in rabbits[J]. J Caratact Refract Surg, 2001, 27(2): 310 -319.
16. 　Netto MV, Mohan RR, Ambrósio R Jr, et al.Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy[J]. Cornea, 2005, 24(5): 509-522.

《華西醫學》

聚乙二醇滴眼液對準分子激光上皮下角膜磨鑲術后角膜霧狀混濁形成的影響

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《華西醫學》

聚乙二醇滴眼液對準分子激光上皮下角膜磨鑲術后角膜霧狀混濁形成的影響

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