實時熒光顯像在膠質瘤術中應用的研究進展_《華西醫學》

作者：

余水 ,  毛慶

四川大學華西醫院神經外科（成都，610041）;

關鍵詞：

δ-氨基-γ-酮戊酸熒光素鈉納米熒光探針靛氰綠多光子膠質瘤術

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

【摘要】膠質瘤是中樞神經系統發病率最高的惡性腫瘤，目前的治療方法是以手術為主、放化療為輔的分級分型個體化綜合治療，其中手術為最快速和有效去除腫瘤組織的手段。由于腫瘤常呈浸潤性生長，術中腫瘤邊界顯示不清，要達到術中全切非常困難。提高腫瘤邊界判斷的準確性，以助于術者最大限度地切除腫瘤，便成為改善患者預后的主要方法。術中實時熒光顯像技術為近年來蓬勃發展的判斷腫瘤邊界的新技術。目前國際上熒光顯像方法主要有δ-氨基-γ-酮戊酸、熒光素鈉、納米熒光探針、靛氰綠、多光子激發熒光等引導的熒光顯像法，前兩者相對較成熟而后三者仍處于研究之中。本文就術中實時熒光顯像在膠質瘤術中應用進行闡述。

引用本文： 余水,毛慶. 實時熒光顯像在膠質瘤術中應用的研究進展. 華西醫學, 2010, 25(7): 1385-1387. doi: 復制

1.	Stummer W, Stocker S, Wagner S, et al. Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence[J]. Surg Neurol, 1998, 42(3): 518-526.
2.	Stummer W, Novotny A, Stepp H, et al. Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients[J]. Neurosurg, 2000, 93: 1003-1013.
3.	Stummer W, Pichlmeier U, Meinel T, et al. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase Ⅲ trial[J]. Lancet Oncol, 2006, 7(5): 392-401.
4.	Kuroiwa T, Kajimoto Y, Ohta T, et al. Development of a fluorescein operative microscope for use during malignant glioma surgery-a technical note and preliminary report[J]. Surg Neurol, 1998, 50(1): 41-49.
5.	Shinoda J, Yano H, Yoshimura S, et al. Fluorescence-guided resection of glioblastoma multiforme by using high-dose fluorescein sodium. Technical note[J]. J Neurosurg, 2003, 99(3): 597-603.
6.	胡新華, 張巖松, 劉翔, 等. 熒光導航輔助下切除功能區惡性膠質瘤[J]. 中國微侵襲神經外科雜志, 2006, 11(8): 343-344.
7.	張巖松, 常義, 劉宏毅, 等. 熒光導航技術在顱內惡性膠質瘤手術中的應用[J]. 臨床神經病學雜志, 2006, 19(1): 56-57.
8.	Okuda T, Kataoka K, Taneda M. Metastatic brain tumor surgery using fluorescein sodium: technical note[J]. Minim Invasive Neurosurg, 2007, 50(6): 382-384.
9.	Moritz F, Mahmood U, Raymond S, et al. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation[J]. Cancer Res, 2003, 63(23): 8122-8125.
10.	Veiseh O, Sun C, Gunn J, et al. Optical and MRI multifunctional nanoprobe for targeting gliomas[J]. Nano Letters, 2005, 5(6): 1003-1008.
11.	Hockaday DC, Shen S, Fiveash J, et al. Imaging glioma extent with 131I-TM-601[J]. Nucl Med, 2005, 46(4): 580-586. [12] Veiseh M, Gabikian P, Bahrami SB, et al. Tumor paint: A chlorotoxin: Cy5. 5 bioconjugate for intraoperative visualization of cancer foci[J]. Cancer Res, 2007, 67(14): 6882-6888.
12.	Hansen D, Spence A, Carski T, et al. Indocyanine green(ICG)staining and demarcation of tumormargins in a rat glioma model[J]. Surg Neurol, 1993, 40(6): 451-456.
13.	Haglund M, Hochman D, Berger M, et al. Enhanced optical imaging of rat gliomas and tumor margins[J]. Neuro Surg, 1994, 35(5): 930-940.
14.	Haglund M, Berger M, Hochman D, et al. Enhanced optical imaging of human gliomas and tumor margins[J]. Neuro Surg, 1996, 38(2): 308-317.
15.	Gavin W, Ghatan S, Alexander M, et al. Intracarotid RMP-7 enhanced indocyanine green staining of tumors in a rat. glioma model[J]. Neurooncol, 2002, 56(3): 227-232.
16.	Leppert J, Krajewski J, Kantelhardt SR, et al. Multiphoton excitation of autofluorescence for microscopy of glioma tissue[J]. Neurosurg, 2006, 58: 759-767.
17.	Ichioka T, Miyatake S, Asai N, et al. Enhanced detection of malignant glioma xenograft by fluorescein-human serum albumin conjugate[J]. J Neurooncol, 2004, 67(1-2): 47-52.
18.	顧小宇, 尚寒冰, 趙衛國, 等. 腦膠質瘤術中熒光顯像的實驗研究[J]. 中國微侵襲神經外科雜志, 2009, 14(10): 456-458.
19.	Park MH, Ahn BH, Hong YK, et al. Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-κB/Sp1-mediated signaling pathways[J]. Carcinogenesis, 2009, 30(2): 356-365.
20.	McGirt MJ, Chaichana KL, Attenello FJ, et al. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas[J]. Neurosurgery, 2008, 63(4): 700-708.
21.	Mcgirt MJ, Chaichana KL, Gathinji M, et al. Independent association of extent of resection with survival in patients with malignant brain astrocytoma[J]. J Neurosurg, 2009, 110(1): 156-162.

1. Stummer W, Stocker S, Wagner S, et al. Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence[J]. Surg Neurol, 1998, 42(3): 518-526.
2. Stummer W, Novotny A, Stepp H, et al. Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients[J]. Neurosurg, 2000, 93: 1003-1013.
3. Stummer W, Pichlmeier U, Meinel T, et al. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase Ⅲ trial[J]. Lancet Oncol, 2006, 7(5): 392-401.
4. Kuroiwa T, Kajimoto Y, Ohta T, et al. Development of a fluorescein operative microscope for use during malignant glioma surgery-a technical note and preliminary report[J]. Surg Neurol, 1998, 50(1): 41-49.
5. Shinoda J, Yano H, Yoshimura S, et al. Fluorescence-guided resection of glioblastoma multiforme by using high-dose fluorescein sodium. Technical note[J]. J Neurosurg, 2003, 99(3): 597-603.
6. 胡新華, 張巖松, 劉翔, 等. 熒光導航輔助下切除功能區惡性膠質瘤[J]. 中國微侵襲神經外科雜志, 2006, 11(8): 343-344.
7. 張巖松, 常義, 劉宏毅, 等. 熒光導航技術在顱內惡性膠質瘤手術中的應用[J]. 臨床神經病學雜志, 2006, 19(1): 56-57.
8. Okuda T, Kataoka K, Taneda M. Metastatic brain tumor surgery using fluorescein sodium: technical note[J]. Minim Invasive Neurosurg, 2007, 50(6): 382-384.
9. Moritz F, Mahmood U, Raymond S, et al. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation[J]. Cancer Res, 2003, 63(23): 8122-8125.
10. Veiseh O, Sun C, Gunn J, et al. Optical and MRI multifunctional nanoprobe for targeting gliomas[J]. Nano Letters, 2005, 5(6): 1003-1008.
11. Hockaday DC, Shen S, Fiveash J, et al. Imaging glioma extent with 131I-TM-601[J]. Nucl Med, 2005, 46(4): 580-586. [12] Veiseh M, Gabikian P, Bahrami SB, et al. Tumor paint: A chlorotoxin: Cy5. 5 bioconjugate for intraoperative visualization of cancer foci[J]. Cancer Res, 2007, 67(14): 6882-6888.
12. Hansen D, Spence A, Carski T, et al. Indocyanine green(ICG)staining and demarcation of tumormargins in a rat glioma model[J]. Surg Neurol, 1993, 40(6): 451-456.
13. Haglund M, Hochman D, Berger M, et al. Enhanced optical imaging of rat gliomas and tumor margins[J]. Neuro Surg, 1994, 35(5): 930-940.
14. Haglund M, Berger M, Hochman D, et al. Enhanced optical imaging of human gliomas and tumor margins[J]. Neuro Surg, 1996, 38(2): 308-317.
15. Gavin W, Ghatan S, Alexander M, et al. Intracarotid RMP-7 enhanced indocyanine green staining of tumors in a rat. glioma model[J]. Neurooncol, 2002, 56(3): 227-232.
16. Leppert J, Krajewski J, Kantelhardt SR, et al. Multiphoton excitation of autofluorescence for microscopy of glioma tissue[J]. Neurosurg, 2006, 58: 759-767.
17. Ichioka T, Miyatake S, Asai N, et al. Enhanced detection of malignant glioma xenograft by fluorescein-human serum albumin conjugate[J]. J Neurooncol, 2004, 67(1-2): 47-52.
18. 顧小宇, 尚寒冰, 趙衛國, 等. 腦膠質瘤術中熒光顯像的實驗研究[J]. 中國微侵襲神經外科雜志, 2009, 14(10): 456-458.
19. Park MH, Ahn BH, Hong YK, et al. Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-κB/Sp1-mediated signaling pathways[J]. Carcinogenesis, 2009, 30(2): 356-365.
20. McGirt MJ, Chaichana KL, Attenello FJ, et al. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas[J]. Neurosurgery, 2008, 63(4): 700-708.
21. Mcgirt MJ, Chaichana KL, Gathinji M, et al. Independent association of extent of resection with survival in patients with malignant brain astrocytoma[J]. J Neurosurg, 2009, 110(1): 156-162.

《華西醫學》

實時熒光顯像在膠質瘤術中應用的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《華西醫學》

實時熒光顯像在膠質瘤術中應用的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料