肝脾γδT細胞淋巴瘤2例并文獻復習_《華西醫學》

作者：

王彩霞 ,  常紅

四川大學華西醫院血液科,四川成都 610041;

關鍵詞：

肝脾γδT細胞淋巴瘤病理學特征免疫表型

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目的:探討肝脾γδT細胞淋巴瘤的臨床表現、病理學特征、免疫表型特點。方法:對我院2例確診的肝脾γδT細胞淋巴瘤患者的臨床資料進行分析、追蹤隨訪并進行文獻復習。結果:該組患者均為青年男性,肝脾不同程度長大,發熱,全血細胞減少(1/2),肝功能受損,淋巴結未受累;病理示瘤細胞彌漫性肝、骨髓的竇內侵犯;免疫表型:患者瘤細胞表達CD2(+)、CD3(+)、CD56(+)、CD16(+)、CD20()、TIA1(+)、TCRγ／δ(+)。結論:肝脾γδT細胞淋巴瘤是較為罕見的外周T細胞淋巴瘤,以肝脾長大、發熱為主要臨床表現,通常淋巴結不受累,病情進展快,療效差,生存期短。

引用本文： 王彩霞,常紅. 肝脾γδT細胞淋巴瘤2例并文獻復習. 華西醫學, 2009, 24(3): 590-592. doi: 復制

1.	JAFE ES.RALTKIAER E.Hepatosplenic T cell lymphoma.In:Jafe ES,Harris NL,Stein H,et al.World Health Organization classification of tumours.Pathology and genetics of tumours ofheamatopoietic and lymphoid tissues[M].Lyon:IARC Press,2001:210-211..
2.	李精明,陳焯文,龐丹梅,等.原發性肝脾T細胞淋巴瘤三例報告并文獻復習[J].白血病.淋巴瘤,2006,15(2):137-138..
3.	BELHADJ K,REYES F,FARCET JP,et al.Hepatosplenic gammadelta Tcell lymphomas is a rare clinicopathologic entity with poor outcome:report on a series of 21 patients[J].Blood,2003,102:4 261-4269..
4.	魏拴增,劉彤華.肝脾γδ和αβ細胞淋巴瘤[J].中華病理學雜志,2003,32(1):62-64..
5.	WEIDMANN E.Hepatosplenic T cell lymphoma.A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990[J].Leukemia,2000,14(6):991-997..
6.	ShuanZeng Wei,TongHua Liu,DeTian Wang,et al.Hepatosplenic γδ Tcell lymphoma[J].World J Gastroenterol,2005,11(24):3729-3734..
7.	GOPCSA L,BANYAI A,TAMASKA J,et al.Hepatosplenic gamma delta Tcekk lymphoma with leukemic phase successfully treated with 2chlorodeoxyadenosine[J].Haematolgia(Budsp),2002,32:519-527..
8.	IANNITTO E,BARBERA V,QUINTINI G,et al.Hepatosplenic gammadelta Tcell lymphoma:complete response induced by treatment with pentoststin[J].Br J Heamatol,2002,117:995996..
9.	GRIGG AP.2’Deoxycoformycin for hepatosplenic gamma delta Tcell lymphoma[J].Leuk Lymphoma,2001,42:797-799..

1. JAFE ES.RALTKIAER E.Hepatosplenic T cell lymphoma.In:Jafe ES,Harris NL,Stein H,et al.World Health Organization classification of tumours.Pathology and genetics of tumours ofheamatopoietic and lymphoid tissues[M].Lyon:IARC Press,2001:210-211..
2. 李精明,陳焯文,龐丹梅,等.原發性肝脾T細胞淋巴瘤三例報告并文獻復習[J].白血病.淋巴瘤,2006,15(2):137-138..
3. BELHADJ K,REYES F,FARCET JP,et al.Hepatosplenic gammadelta Tcell lymphomas is a rare clinicopathologic entity with poor outcome:report on a series of 21 patients[J].Blood,2003,102:4 261-4269..
4. 魏拴增,劉彤華.肝脾γδ和αβ細胞淋巴瘤[J].中華病理學雜志,2003,32(1):62-64..
5. WEIDMANN E.Hepatosplenic T cell lymphoma.A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990[J].Leukemia,2000,14(6):991-997..
6. ShuanZeng Wei,TongHua Liu,DeTian Wang,et al.Hepatosplenic γδ Tcell lymphoma[J].World J Gastroenterol,2005,11(24):3729-3734..
7. GOPCSA L,BANYAI A,TAMASKA J,et al.Hepatosplenic gamma delta Tcekk lymphoma with leukemic phase successfully treated with 2chlorodeoxyadenosine[J].Haematolgia(Budsp),2002,32:519-527..
8. IANNITTO E,BARBERA V,QUINTINI G,et al.Hepatosplenic gammadelta Tcell lymphoma:complete response induced by treatment with pentoststin[J].Br J Heamatol,2002,117:995996..
9. GRIGG AP.2’Deoxycoformycin for hepatosplenic gamma delta Tcell lymphoma[J].Leuk Lymphoma,2001,42:797-799..

《華西醫學》

肝脾γδT細胞淋巴瘤2例并文獻復習

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《華西醫學》

肝脾γδT細胞淋巴瘤2例并文獻復習

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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Content

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