阿魏酸哌嗪對環孢霉素A慢性腎毒性的影響_《華西醫學》

作者：

四川大學華西醫學院腎內科,四川成都 610041;

關鍵詞：

環孢霉素A 慢性腎毒性阿魏酸哌嗪

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的:探討阿魏酸哌嗪對環孢霉素A（CsA）慢性腎毒性的保護作用。方法:按四組分別給予實驗大鼠橄欖油,CsA,CsA加低劑量阿魏酸哌嗪［50 mg/（kg·d）］及CsA加高劑量阿魏酸哌嗪［100 mg/（kg·d）］,四周后取血測血肌酐,計算肌酐清除率,取腎組織測定腎組織和血中的血管緊張素Ⅱ濃度,同時作腎組織病理學檢查。通過免疫組化觀察腎組織內皮素及Ⅲ型膠原表達情況。結果:CsA大鼠腎臟可見明顯損傷,同時肌酐清除率明顯下降,血漿及腎組織血管緊張素Ⅱ含量增高,而且腎組織局部內皮素及Ⅲ型膠原表達明顯增高。給予阿魏酸哌嗪能使腎損傷有所減輕,使血液及腎組織血管緊張素Ⅱ含量減少,內皮素及Ⅲ型膠原表達下降。結論:CsA引起慢性腎毒性可能與血管緊張素Ⅱ、內皮素和Ⅲ型膠原增加有關,同時應用阿魏酸哌嗪可以使血漿及腎臟組織血管緊張素Ⅱ減少,內皮素和Ⅲ型膠原表達下降,因此對腎臟有保護作用,而且這種作用與劑量有相關性。

引用本文： 薄虹,陶冶,劉其峰,王雪榮,李晶. 阿魏酸哌嗪對環孢霉素A慢性腎毒性的影響. 華西醫學, 2009, 24(3): 677-680. doi: 復制

1.	BENNETT W M.Clinical aspects of cyclosporine nephrotoxicity[J].Nephrology,1991,1:564..
2.	BURDMANN EA, ANDOH TF, NAST CC,et al.Prevention of experimental cyclosporininduced interstitial fibrosis by losartan and enalapril[J].Am J Physiol,1995,269:F491-499..
3.	LEE DBN.Cyclosporine and the renin angiotensin axis[J].Kidney Int,1997,52:248-260..
4.	BENNETT WM, DEMATTOS A, MEYER MM,et al.Chronic cyclosporine nephropathy: the Achilles heel of immunosuppressive therapy[J]. Kidney Int,1996,50,1089-1100..
5.	KURTZ A, BRUNA RD, KüHN K.Cyclosporine A enhances renin secretion and production in isolated juxtaglomerular cells[J].Kidney Int, 1988,33:947-953..
6.	BURDMANN EA, ANDOH TF,et al.Prevention of experimental cyclosporininduced interstitial fibrosis by losartan and enalapril[J].Am J Physiol,1995,269:F491-F499..
7.	SHIHAB FS, ANDOH TF, TANNER AM,et al.Role of transforming growth factorβ1 in experimental chronic cyclosporine nephropathy[J]. Kidney Int,1996,49:1141-1151..
8.	HEALY E, DEMPSEY M, LALLY C,et al.Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line[J].Kidney Int,1998,54:1955-1966..
9.	KON V, SUGIURA M, INAGAMI T,et al.Role of endothelin in cyclosporineinduced glomerular dysfunction[J].Kidney Int,1990,37:1487-1491.
10.	王峰,劉敏,楊連春.新的非肽類內皮素拮抗劑:咖啡酸、阿魏酸[J].藥學學報,1999,34:898-901..
11.	GHIGGERI G M, ALTIERI P, OLEGGINI R,et al.Cyclosporine enhances the synthesis of selected extracellular matrix proteins by renal cells in culture[J].Transplantation, 1994,57:13821388..
12.	OLEGGINI R, MUSANTE L,MENONI S,et al.Characterization of a DNA binding site that mediates the stimulatory effect of cyclosporinA on type Ⅲ collagen expression in renal cells[J].Nephrol Dial Transplant,2000,15: 778-785..
13.	KLAHR S, MORRISSEY J J.The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease[J].Kidney Int,2000,75（Suppl）:S7-S14..

1. BENNETT W M.Clinical aspects of cyclosporine nephrotoxicity[J].Nephrology,1991,1:564..
2. BURDMANN EA, ANDOH TF, NAST CC,et al.Prevention of experimental cyclosporininduced interstitial fibrosis by losartan and enalapril[J].Am J Physiol,1995,269:F491-499..
3. LEE DBN.Cyclosporine and the renin angiotensin axis[J].Kidney Int,1997,52:248-260..
4. BENNETT WM, DEMATTOS A, MEYER MM,et al.Chronic cyclosporine nephropathy: the Achilles heel of immunosuppressive therapy[J]. Kidney Int,1996,50,1089-1100..
5. KURTZ A, BRUNA RD, KüHN K.Cyclosporine A enhances renin secretion and production in isolated juxtaglomerular cells[J].Kidney Int, 1988,33:947-953..
6. BURDMANN EA, ANDOH TF,et al.Prevention of experimental cyclosporininduced interstitial fibrosis by losartan and enalapril[J].Am J Physiol,1995,269:F491-F499..
7. SHIHAB FS, ANDOH TF, TANNER AM,et al.Role of transforming growth factorβ1 in experimental chronic cyclosporine nephropathy[J]. Kidney Int,1996,49:1141-1151..
8. HEALY E, DEMPSEY M, LALLY C,et al.Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line[J].Kidney Int,1998,54:1955-1966..
9. KON V, SUGIURA M, INAGAMI T,et al.Role of endothelin in cyclosporineinduced glomerular dysfunction[J].Kidney Int,1990,37:1487-1491.
10. 王峰,劉敏,楊連春.新的非肽類內皮素拮抗劑:咖啡酸、阿魏酸[J].藥學學報,1999,34:898-901..
11. GHIGGERI G M, ALTIERI P, OLEGGINI R,et al.Cyclosporine enhances the synthesis of selected extracellular matrix proteins by renal cells in culture[J].Transplantation, 1994,57:13821388..
12. OLEGGINI R, MUSANTE L,MENONI S,et al.Characterization of a DNA binding site that mediates the stimulatory effect of cyclosporinA on type Ⅲ collagen expression in renal cells[J].Nephrol Dial Transplant,2000,15: 778-785..
13. KLAHR S, MORRISSEY J J.The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease[J].Kidney Int,2000,75（Suppl）:S7-S14..

《華西醫學》

阿魏酸哌嗪對環孢霉素A慢性腎毒性的影響

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《華西醫學》

阿魏酸哌嗪對環孢霉素A慢性腎毒性的影響

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料