鹽敏感性高血壓患者胰島素抵抗與脂聯素水平的關系_《華西醫學》

作者：

王勉 , 陳曉平

四川大學華西醫院心內科,四川成都 610041;

關鍵詞：

高血壓鹽敏感胰島素抵抗脂聯素

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目的:探討鹽敏感性高血壓患者胰島素抵抗與脂聯素代謝異常的關系。方法:對100例高血壓患者采用急性鹽水負荷試驗,確定65例為鹽敏感性(SS)高血壓患者,35例為鹽不敏感性(NSS)高血壓患者,選定正常人50例為對照組,分別測其胰島素水平、血脂、血尿酸及脂聯素水平。結果:高血壓患者存尿酸、膽固醇、甘油三酯水平升高(P lt;0.01),SS組較NSS組的血尿酸、血膽固醇、血甘油三脂增高(P lt;0.01)。SS組脂聯素［(6.04±2.08)ng/mL］,較NSS組［(7.89±3.35)ng/mL(P lt;0.01)］降低,且SS組存在胰島素抵抗,HOMA指數分別為［2.54±0.53,2.21±0.55(P lt;0.01)］。血漿脂聯素水平與胰島素抵抗指標存在正相關,r=-0.36,(P lt;0.01)。結論:鹽敏感性高血壓患者存在胰島素抵抗及脂聯素降低,胰島素抵抗可能是其他代謝異常及脂聯素降低的基礎。

引用本文： 王勉,陳曉平. 鹽敏感性高血壓患者胰島素抵抗與脂聯素水平的關系. 華西醫學, 2009, 24(7): 1714-1716. doi: 復制

1.	UZU T, KAZEMBE FS, ISHIKAWA K, et al. High sodium sensitivity implicates nocturnal hypertension in essential hypertension[J]. Hypertension, 1996, 28:139-142.
2.	BILHORAC A, TEZCAN H, OZENER, et al. Association between salt sensitivity and target organ damage in essential hypertension[J]. Am J Hypertens, 2000, 13:846-872.
3.	JOHN S W, KREGE J H, OLIVER P M, et al. Genetic decreases in atrial natriuretic peptide and saltsensitive hypertension[J]. Science, 1995, 267:679-681.
4.	GALISTEO M, GARCIASAURA M F, JIMENEZ R, et al. Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetatesalthypertensive rats[J]. Mol Cell Biochem, 2004, 259:91-99.
5.	ZHOU M S, JAIMES E A, RAIJ L. Atorvastatin prevents endorgan injury in saltsensitive hypertension:role of eNOS and oxidant stress[J]. Hypertension, 2004, 44:186-90.
6.	劉文輝, 劉治全, 等. 慢性鹽負荷對血壓正常鹽敏感性個體胰島素抗性的影響[J ]. 高血壓雜志, 1998, 6 (2):1111.
7.	OHASHIK, KIHARA S, OUCHIN, et al. Adiponection replenishmenl amelionatca obeaityrelated hypentension [J]. Hypentension. 2006,47(6):1108-1116.
8.	ADAMCZAK M, WIECEK A, FUNAHASHI T, et al.〖WTBZ〗Decreased plasmal.adiponectin concent ration in patients with essential hypertension[J]. Am J hypertens,2003,16(1),72-75.

1. UZU T, KAZEMBE FS, ISHIKAWA K, et al. High sodium sensitivity implicates nocturnal hypertension in essential hypertension[J]. Hypertension, 1996, 28:139-142.
2. BILHORAC A, TEZCAN H, OZENER, et al. Association between salt sensitivity and target organ damage in essential hypertension[J]. Am J Hypertens, 2000, 13:846-872.
3. JOHN S W, KREGE J H, OLIVER P M, et al. Genetic decreases in atrial natriuretic peptide and saltsensitive hypertension[J]. Science, 1995, 267:679-681.
4. GALISTEO M, GARCIASAURA M F, JIMENEZ R, et al. Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetatesalthypertensive rats[J]. Mol Cell Biochem, 2004, 259:91-99.
5. ZHOU M S, JAIMES E A, RAIJ L. Atorvastatin prevents endorgan injury in saltsensitive hypertension:role of eNOS and oxidant stress[J]. Hypertension, 2004, 44:186-90.
6. 劉文輝, 劉治全, 等. 慢性鹽負荷對血壓正常鹽敏感性個體胰島素抗性的影響[J ]. 高血壓雜志, 1998, 6 (2):1111.
7. OHASHIK, KIHARA S, OUCHIN, et al. Adiponection replenishmenl amelionatca obeaityrelated hypentension [J]. Hypentension. 2006,47(6):1108-1116.
8. ADAMCZAK M, WIECEK A, FUNAHASHI T, et al.〖WTBZ〗Decreased plasmal.adiponectin concent ration in patients with essential hypertension[J]. Am J hypertens,2003,16(1),72-75.

《華西醫學》

鹽敏感性高血壓患者胰島素抵抗與脂聯素水平的關系

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《華西醫學》

鹽敏感性高血壓患者胰島素抵抗與脂聯素水平的關系

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Content

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