TRAIL信號通路在胃癌的研究現狀_《中國普外基礎與臨床雜志》

作者：

陳心足 ¹ , 姜坤 ² , 胡建昆 ¹

1.四川大學華西醫院普外三科(成都610041);;
2.四川大學華西醫院中西醫結合科;

關鍵詞：

胃癌凋亡腫瘤壞死因子相關凋亡誘導配體信號通路

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　介紹腫瘤壞死因子相關凋亡誘導配體(TRAIL)及其受體在胃癌的研究現狀。
方法　檢索PUB-MEDLINE和中國期刊全文數據庫(CJFD)，綜述國內、外近年關于TRAIL及其受體在胃癌的相關研究文獻。
結果　TRAIL在胃癌組織表達水平報道情況差異較大，但其與胃癌的分化程度和浸潤、轉移情況密切相關。其受體DR4及DR5在胃癌組織均表達陽性，而DcR1及DcR2在胃癌組織亦有表達陽性的報道。caspase-3、caspase-8和survivin對胃癌TRAIL信號通路有重要調節作用。5-氮-2′-雜脫氧胞苷、阿霉素、5-氟尿嘧啶、α-生育酚及X射線照射可協同增強TRAIL對胃癌細胞的凋亡誘導作用。
結論　胃癌可能適合TRAIL靶向治療，但其作用機理較為復雜并受到多因素影響。尚有如何有效增強和調控TRAIL凋亡誘導作用及TRAIL有何潛在毒性等諸多問題亟待研究。

引用本文： 陳心足,姜坤,胡建昆. TRAIL信號通路在胃癌的研究現狀. 中國普外基礎與臨床雜志, 2007, 14(3): 371-375. doi: 復制

1.	Gores GJ, Kaufmann SH. Is TRAIL hepatotoxic? [J]. Hepatology， 2001; 34(1)∶3.
2.	Parkin DM. Global cancer statistics in the year 2000 [J]. Lancet Oncol， 2001; 2(9)∶533.
3.	孫秀娣, 牧人, 周有尚, 等. 中國胃癌死亡率20年變化情況分析及其發展趨勢預測 [J]. 中華腫瘤雜志, 2004; 26(1)∶4.
4.	Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis [J]. Immunity， 1995; 3(6)∶673.
5.	Kimberley FC, Screaton GR. Following a TRAIL: update on a ligand and its five receptors [J]. Cell Res， 2004; 14(5)∶359.
6.	Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors [J]. Science， 1997; 277(5327)∶818.
7.	僧靖靜，張云漢，高冬玲. TRAIL、 Survivin mRNA表達與胃癌凋亡發生的相關關系 [J]. 河南大學學報(醫學科學版)， 2005; 24(1)∶25.
8.	Yoo NJ, Kim HS, Kim SY, et al. Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas [J]. APMIS， 2003; 111(3)∶382.
9.	Sinicrope FA, Penington RC, Tang XM. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells [J]. Clin Cancer Res， 2004; 10(24)∶8284.
10.	Koyama S, Koike N, Adachi S. Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor [J]. J Cancer Res Clin Oncol， 2002; 128(2)∶73.
11.	張淑紅, 周世慶, 真巖波, 等. 胃癌細胞Trail表達與細胞凋亡檢測結果分析 [J]. 山東醫藥, 2002; 42(21)∶27.
12.	劉勝雄, 湯明, 吳飛躍. TRAIL在胃癌中的表達及其意義 [J]. 中國普通外科雜志, 2005; 14(10)∶789.
13.	程文芳, 易粹瓊. 腫瘤壞死因子相關凋亡誘導配體的受體在胃癌中的表達 [J]. 中華內科雜志, 2003; 42(2)∶118.
14.	Kuraoka K, Matsumura S, Sanada Y, et al. A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan [J]. Oncol Rep， 2005; 14(2)∶465.
15.	Park WS, Lee JH, Shin MS, et al. Inactivating mutations of KILLER/DR5 gene in gastric cancers [J]. Gastroenterology， 2001; 121(5)∶1219.
16.	張汝鋼, 房殿春, 楊柳芹, 等. 5-Aza-CdR增強TRAIL對胃癌細胞的抗瘤活性與caspase-8表達的關系 [J]. 第三軍醫大學學報, 2005; 27(2)∶95.
17.	Harada K, Toyooka S, Shivapurkar N, et al. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines [J]. Cancer Res， 2002; 62(20)∶5897.
18.	Zuzak TJ, Steinhoff DF, Sutton LN, et al. Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma [J]. Eur J Cancer， 2002; 38(1)∶83.
19.	Fulda S, Kufer MU, Meyer E, et al. Sensitization for death receptor-or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer [J]. Oncogene， 2001; 20(41)∶5865.
20.	張汝鋼, 房殿春, 楊柳芹, 等. 5-Aza-CdR可提高TRAIL對胃癌細胞Kato3的抗瘤活性 [J]. 重慶醫學, 2003; 32(9)∶1141.
21.	張汝鋼, 房殿春, 楊柳芹, 等. 胃癌細胞對TRAIL的敏感性與caspase-8基因甲基化狀態的關系 [J]. 第三軍醫大學學報, 2004; 26(2)∶95.
22.	Kanehara I, Nakata B, Hirakawa K. Caspase-8 is scarcely silenced and its activity is well correlated with the anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand in gastric cancer cells [J]. Oncol Rep， 2005; 14(5)∶1249.
23.	楊柳芹, 房殿春, 張汝鋼, 等. 胃癌細胞bcl-2和Caspase3的表達對TRAIL抗瘤作用的影響 [J]. 重慶醫學, 2003; 32(9)∶1132.
24.	Yang LQ, Fang DC, Wang RQ, et al. Effect of NF-kappaB, survivin, Bcl-2 and Caspase3 on apoptosis of gastric cancer cells induced by tumor necrosis factor related apoptosis inducing ligand [J]. World J Gastroenterol， 2004; 10(1)∶22.
25.	Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med， 1997; 3(8)∶917.
26.	楊柳芹, 房殿春. 胃癌細胞NF-κB和survivin的表達對TRAIL抗瘤作用的影響 [J]. 第三軍醫大學學報, 2004; 26(7)∶584.
27.	程文芳, 易粹瓊. 死亡配體TRAIL誘導胃癌細胞凋亡的研究 [J]. 中華消化內鏡雜志, 2002; 19(4)∶229.
28.	程文芳, 易粹瓊. 腫瘤壞死因子相關凋亡誘導配體誘導人胃癌耐藥細胞凋亡的研究 [J]. 中華消化雜志, 2003; 23(10)∶590.
29.	Nam SY, Jung GA, Hur GC, et al. Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers [J]. Cancer Sci， 2003; 94(12)∶1066.
30.	僧靖靜, 張云漢, 高冬玲. TRAIL聯合化療藥物誘導人胃癌細胞系BGC-823凋亡觀察 [J]. 鄭州大學學報(醫學版), 2005; 40(3)∶442.
31.	Anderson K, Simmons-Menchaca M, Lawson KA, et al. Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E Succinate and vitamin E analogue, alpha-TEA [J]. Cancer Res， 2004; 64(12)∶4263.
32.	Tomasetti M, Rippo MR, Alleva R, et al. Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells [J]. Br J Cancer， 2004; 90(8)∶1644.
33.	楊柳芹, 房殿春. α-生育酚對TRAIL誘導胃癌細胞凋亡的影響及機制 [J]. 　解放軍醫學雜志, 2005; 30(9)∶779.
34.	Hamasu T, Inanami O, Asanuma T, et al. Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists [J]. J Radiat Res, 2005; 46(1)∶103.
35.	王正兵, 賈筱琴, 陳兵, 等. TRAIL真核表達質粒的構建及抑制肝癌生長的實驗研究 [J]. 中國普外基礎與臨床雜志, 2005; 12（3）∶261.
36.	公偉，劉軍，梁飛，等. TRAIL受體在胰腺癌中的表達 [J]. 中國普外基礎與臨床雜志, 2006; 13(5)∶521.

1. Gores GJ, Kaufmann SH. Is TRAIL hepatotoxic? [J]. Hepatology， 2001; 34(1)∶3.
2. Parkin DM. Global cancer statistics in the year 2000 [J]. Lancet Oncol， 2001; 2(9)∶533.
3. 孫秀娣, 牧人, 周有尚, 等. 中國胃癌死亡率20年變化情況分析及其發展趨勢預測 [J]. 中華腫瘤雜志, 2004; 26(1)∶4.
4. Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis [J]. Immunity， 1995; 3(6)∶673.
5. Kimberley FC, Screaton GR. Following a TRAIL: update on a ligand and its five receptors [J]. Cell Res， 2004; 14(5)∶359.
6. Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors [J]. Science， 1997; 277(5327)∶818.
7. 僧靖靜，張云漢，高冬玲. TRAIL、 Survivin mRNA表達與胃癌凋亡發生的相關關系 [J]. 河南大學學報(醫學科學版)， 2005; 24(1)∶25.
8. Yoo NJ, Kim HS, Kim SY, et al. Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas [J]. APMIS， 2003; 111(3)∶382.
9. Sinicrope FA, Penington RC, Tang XM. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells [J]. Clin Cancer Res， 2004; 10(24)∶8284.
10. Koyama S, Koike N, Adachi S. Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor [J]. J Cancer Res Clin Oncol， 2002; 128(2)∶73.
11. 張淑紅, 周世慶, 真巖波, 等. 胃癌細胞Trail表達與細胞凋亡檢測結果分析 [J]. 山東醫藥, 2002; 42(21)∶27.
12. 劉勝雄, 湯明, 吳飛躍. TRAIL在胃癌中的表達及其意義 [J]. 中國普通外科雜志, 2005; 14(10)∶789.
13. 程文芳, 易粹瓊. 腫瘤壞死因子相關凋亡誘導配體的受體在胃癌中的表達 [J]. 中華內科雜志, 2003; 42(2)∶118.
14. Kuraoka K, Matsumura S, Sanada Y, et al. A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan [J]. Oncol Rep， 2005; 14(2)∶465.
15. Park WS, Lee JH, Shin MS, et al. Inactivating mutations of KILLER/DR5 gene in gastric cancers [J]. Gastroenterology， 2001; 121(5)∶1219.
16. 張汝鋼, 房殿春, 楊柳芹, 等. 5-Aza-CdR增強TRAIL對胃癌細胞的抗瘤活性與caspase-8表達的關系 [J]. 第三軍醫大學學報, 2005; 27(2)∶95.
17. Harada K, Toyooka S, Shivapurkar N, et al. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines [J]. Cancer Res， 2002; 62(20)∶5897.
18. Zuzak TJ, Steinhoff DF, Sutton LN, et al. Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma [J]. Eur J Cancer， 2002; 38(1)∶83.
19. Fulda S, Kufer MU, Meyer E, et al. Sensitization for death receptor-or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer [J]. Oncogene， 2001; 20(41)∶5865.
20. 張汝鋼, 房殿春, 楊柳芹, 等. 5-Aza-CdR可提高TRAIL對胃癌細胞Kato3的抗瘤活性 [J]. 重慶醫學, 2003; 32(9)∶1141.
21. 張汝鋼, 房殿春, 楊柳芹, 等. 胃癌細胞對TRAIL的敏感性與caspase-8基因甲基化狀態的關系 [J]. 第三軍醫大學學報, 2004; 26(2)∶95.
22. Kanehara I, Nakata B, Hirakawa K. Caspase-8 is scarcely silenced and its activity is well correlated with the anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand in gastric cancer cells [J]. Oncol Rep， 2005; 14(5)∶1249.
23. 楊柳芹, 房殿春, 張汝鋼, 等. 胃癌細胞bcl-2和Caspase3的表達對TRAIL抗瘤作用的影響 [J]. 重慶醫學, 2003; 32(9)∶1132.
24. Yang LQ, Fang DC, Wang RQ, et al. Effect of NF-kappaB, survivin, Bcl-2 and Caspase3 on apoptosis of gastric cancer cells induced by tumor necrosis factor related apoptosis inducing ligand [J]. World J Gastroenterol， 2004; 10(1)∶22.
25. Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med， 1997; 3(8)∶917.
26. 楊柳芹, 房殿春. 胃癌細胞NF-κB和survivin的表達對TRAIL抗瘤作用的影響 [J]. 第三軍醫大學學報, 2004; 26(7)∶584.
27. 程文芳, 易粹瓊. 死亡配體TRAIL誘導胃癌細胞凋亡的研究 [J]. 中華消化內鏡雜志, 2002; 19(4)∶229.
28. 程文芳, 易粹瓊. 腫瘤壞死因子相關凋亡誘導配體誘導人胃癌耐藥細胞凋亡的研究 [J]. 中華消化雜志, 2003; 23(10)∶590.
29. Nam SY, Jung GA, Hur GC, et al. Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers [J]. Cancer Sci， 2003; 94(12)∶1066.
30. 僧靖靜, 張云漢, 高冬玲. TRAIL聯合化療藥物誘導人胃癌細胞系BGC-823凋亡觀察 [J]. 鄭州大學學報(醫學版), 2005; 40(3)∶442.
31. Anderson K, Simmons-Menchaca M, Lawson KA, et al. Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E Succinate and vitamin E analogue, alpha-TEA [J]. Cancer Res， 2004; 64(12)∶4263.
32. Tomasetti M, Rippo MR, Alleva R, et al. Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells [J]. Br J Cancer， 2004; 90(8)∶1644.
33. 楊柳芹, 房殿春. α-生育酚對TRAIL誘導胃癌細胞凋亡的影響及機制 [J]. 　解放軍醫學雜志, 2005; 30(9)∶779.
34. Hamasu T, Inanami O, Asanuma T, et al. Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists [J]. J Radiat Res, 2005; 46(1)∶103.
35. 王正兵, 賈筱琴, 陳兵, 等. TRAIL真核表達質粒的構建及抑制肝癌生長的實驗研究 [J]. 中國普外基礎與臨床雜志, 2005; 12（3）∶261.
36. 公偉，劉軍，梁飛，等. TRAIL受體在胰腺癌中的表達 [J]. 中國普外基礎與臨床雜志, 2006; 13(5)∶521.

《中國普外基礎與臨床雜志》

TRAIL信號通路在胃癌的研究現狀

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

TRAIL信號通路在胃癌的研究現狀

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料