結直腸癌組織Tob mRNA表達的研究_《中國普外基礎與臨床雜志》

作者：

吳殿超 , 周總光 , 鄭雪蓮 , 王俊峰

四川大學華西醫院普外科，消化外科實驗室（成都610041）;

關鍵詞：

結直腸癌 Tob mRNA表達

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目的研究Tob mRNA在結直腸癌組織及其相應的距腫瘤10 cm以遠并經病理學證實的正常組織中的表達，探討其在結直腸癌發生、發展中的作用。
方法用熒光定量RTPCR方法檢測31例結直腸癌標本及其相應的正常組織中Tob mRNA的表達。
結果31例癌組織中Tob mRNA表達高于正常組織（t=3.97，P=0.000）； Tob mRNA表達隨著Dukes分期有增高趨勢，差異有統計學意義(F=3.366，P=0.033)。
結論在結直腸癌的發病機理中，Tob mRNA可能為致癌基因。

引用本文： 吳殿超,周總光,鄭雪蓮,王俊峰. 結直腸癌組織Tob mRNA表達的研究. 中國普外基礎與臨床雜志, 2006, 13(3): 302-304. doi: 復制

1.	Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis [Ｊ]. Cell, 1990; 61(5)∶759.
2.	Matsuda S, KawamuraTsuzuku J, Ohsugi M, et al. Tob, a novel protein that interacts with p185erbB2, is associated with antiproliferative activity [Ｊ]. Oncogene, 1996; 12(4)∶705.
3.	Iwanaga K, Sueoka N, Sato A, et al. Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer [Ｊ]. Cancer Lett, 2003; 202(1)∶71.
4.	來茂德. 中國結直腸癌發生發展相關基因 [Ｊ]. 世界華人消化雜志， 2001； 9（11）∶1227.
5.	Matsuda S, Rouault J, Magaud J, et al. In search of a function for the TIS21/PC3/BTG1/TOB family [Ｊ]. FEBS Lett, 2001; 497(2-3)∶67.
6.	Fong KM, Kida Y, Zimmerman PV, et al. Loss of heterozygosity frequently affects chromosome 17q in nonsmall cell lung cancer [Ｊ]. Cancer Res, 1995; 55(19)∶4268.
7.	Yoshida Y, Nakamura T, Komoda M, et al. Mice lacking a transcriptional corepressor Tob are predisposed to cancer [Ｊ]. Genes Dev, 2003; 17(10)∶1201.
8.	Ahn SH, Sawada H, Ro JY, et al. Differential expression of annexin I in human mammary ductal epithelial cells in normal and benign and malignant breast tissues [Ｊ]. Clin Exp Metastasis, 1997; 15(2)∶151.
9.	Masaki T, Tokuda M, Ohnishi M, et al. Enhanced expression of the protein kinase substrate annexin in human hepatocellular carcinoma [Ｊ]. Hepatology, 1996; 24(1)∶72.
10.	Xia SH, Hu LP, Hu H, et al. Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but downregulated in esophageal squamous cell carcinomas [Ｊ]. Oncogene, 2002; 21(43)∶6641.
11.	Paweletz CP, Ornstein DK, Roth MJ, et al. Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma [Ｊ]. Cancer Res, 2000; 60(22)∶6293.
12.	Roninson IB. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumourpromoting activities of stromal fibroblasts [Ｊ]. Cancer Lett, 2002; 179(1)∶1.

1. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis [Ｊ]. Cell, 1990; 61(5)∶759.
2. Matsuda S, KawamuraTsuzuku J, Ohsugi M, et al. Tob, a novel protein that interacts with p185erbB2, is associated with antiproliferative activity [Ｊ]. Oncogene, 1996; 12(4)∶705.
3. Iwanaga K, Sueoka N, Sato A, et al. Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer [Ｊ]. Cancer Lett, 2003; 202(1)∶71.
4. 來茂德. 中國結直腸癌發生發展相關基因 [Ｊ]. 世界華人消化雜志， 2001； 9（11）∶1227.
5. Matsuda S, Rouault J, Magaud J, et al. In search of a function for the TIS21/PC3/BTG1/TOB family [Ｊ]. FEBS Lett, 2001; 497(2-3)∶67.
6. Fong KM, Kida Y, Zimmerman PV, et al. Loss of heterozygosity frequently affects chromosome 17q in nonsmall cell lung cancer [Ｊ]. Cancer Res, 1995; 55(19)∶4268.
7. Yoshida Y, Nakamura T, Komoda M, et al. Mice lacking a transcriptional corepressor Tob are predisposed to cancer [Ｊ]. Genes Dev, 2003; 17(10)∶1201.
8. Ahn SH, Sawada H, Ro JY, et al. Differential expression of annexin I in human mammary ductal epithelial cells in normal and benign and malignant breast tissues [Ｊ]. Clin Exp Metastasis, 1997; 15(2)∶151.
9. Masaki T, Tokuda M, Ohnishi M, et al. Enhanced expression of the protein kinase substrate annexin in human hepatocellular carcinoma [Ｊ]. Hepatology, 1996; 24(1)∶72.
10. Xia SH, Hu LP, Hu H, et al. Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but downregulated in esophageal squamous cell carcinomas [Ｊ]. Oncogene, 2002; 21(43)∶6641.
11. Paweletz CP, Ornstein DK, Roth MJ, et al. Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma [Ｊ]. Cancer Res, 2000; 60(22)∶6293.
12. Roninson IB. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumourpromoting activities of stromal fibroblasts [Ｊ]. Cancer Lett, 2002; 179(1)∶1.

《中國普外基礎與臨床雜志》

結直腸癌組織Tob mRNA表達的研究

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《中國普外基礎與臨床雜志》

結直腸癌組織Tob mRNA表達的研究

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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