哮喘患者脂聯素水平的變化及意義_《中國呼吸與危重監護雜志》

作者：

丁念昌 , 鄧星奇 , 周玲 , 顧薇 , 李艷艷

上海市閔行區中心醫院急診科( 上海201199) 通信作者: 鄧星奇, E-mail: dengchengsheng@ sina. com;

關鍵詞：

哮喘脂聯素腫瘤壞死因子α

DOI：

DOI: 10 . 7507 /1671 -6205 . 20130108

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的測定哮喘急性發作期和哮喘緩解期患者脂聯素水平, 探討脂聯素在哮喘發病機制中的作用。
方法收集2010 年10 月至2011 年9 月期間在上海市閔行區中心醫院就診的哮喘患者97 例, 其中急性發作期50 例, 緩解期47 例, 另選同期非吸煙健康體檢者27 例作為對照。用ELISA法檢測血清脂聯素與腫瘤壞死因子α( TNF-α) 水平, 同時測定肺功能( FEV1% pred、RV% pred) , 分析脂聯素水平和TNF-α、肺功能之間的相關性。應用SPSS 19. 0 軟件進行統計學分析, 多組數據間比較采用單因素方差分析, 采用Pearson 相關分析進行相關性檢驗。
結果哮喘急性發作期組血清脂聯素濃度[ ( 2. 46 ±1. 21) ng/mL] 低于緩解期組[ ( 3. 79 ±0. 96) ng/mL] 和健康對照組[ ( 9. 64 ±4. 88) ng/mL] ( P 均 lt;0. 01) , 哮喘緩解期組血漿脂聯素濃度低于健康對照組( P lt; 0. 01) 。哮喘急性發作期組及緩解期組血清脂聯素與TNF-α、RV% pred 呈負相關( P lt; 0. 01) , 與FEV1% pred 呈正相關( P lt;0. 01) 。
結論哮喘患者血清脂聯素水平降低, 脂聯素在哮喘中可能起保護作用。

引用本文： 丁念昌,鄧星奇,周玲,顧薇,李艷艷. 哮喘患者脂聯素水平的變化及意義. 中國呼吸與危重監護雜志, 2013, 12(5): 451-453. doi: DOI: 10 . 7507 /1671 -6205 . 20130108 復制

1.	Scherer PE, Williams S , Fogilano M , et al. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem,1995, 270: 26746-26749.
2.	Wamer SM, Knight DA. Airway modeling and remodeling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol, 2008,8: 44-48.
3.	中華醫學會呼吸病學分會哮喘學組. 支氣管哮喘防治指南. 中華結核和呼吸雜志, 2008 , 31: 177-185.
4.	Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol, 2005, 115 : 925-927.
5.	Miller M, Cho JY, Pham A, et al. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol, 2009,182:684-691.
6.	謝娟, 鄧星奇, 龍威, 等, 慢性阻塞性肺疾病患者血漿脂聯素水平及其與白介素17 的相關性. 中國呼吸與危重監護雜志,2011, 10: 21 -24 .
7.	郭茂清, 朱述陽. 脂聯素對氣道平滑肌細胞增殖作用及一磷酸腺苷活化蛋白激酶活性的影響. 中國呼吸與危重監護雜志,2010, 9: 264 -267.
8.	Silvestri M, Bontempelli M, Giacomelll M, et al. High serum levels of tumour necrosls factor-alpha and interleukin-8 in severe asthma: markers of systemic inflammation. Clin Exp Allergy, 2006, 36: 1373-1381.
9.	Havel PJ. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol, 2002, 13: 51 -59.
10.	Enqeli S, Feldpausch M, Gorzelniak K, et al. Association between adiponectin and mediators of inflammation in obese women.Diabetes, 2003, 52 : 942-947.
11.	James A. Airway remodeling in asthma. Curr Opin Pulm Med,2005, 11: 1-6.
12.	Shore SA, Terry RD, Flynt L, et al. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol, 2006, 118: 389 -395.
13.	Summer R, Little FF, Ouchi N, et al. Alveolar macrophage activation and an emphysema-like phenotype in adiponectindeficient mice. Am J Physiol Lung Cell Mol Physiol, 2008, 294 :L1035-L1042.

1. Scherer PE, Williams S , Fogilano M , et al. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem,1995, 270: 26746-26749.
2. Wamer SM, Knight DA. Airway modeling and remodeling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol, 2008,8: 44-48.
3. 中華醫學會呼吸病學分會哮喘學組. 支氣管哮喘防治指南. 中華結核和呼吸雜志, 2008 , 31: 177-185.
4. Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol, 2005, 115 : 925-927.
5. Miller M, Cho JY, Pham A, et al. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol, 2009,182:684-691.
6. 謝娟, 鄧星奇, 龍威, 等, 慢性阻塞性肺疾病患者血漿脂聯素水平及其與白介素17 的相關性. 中國呼吸與危重監護雜志,2011, 10: 21 -24 .
7. 郭茂清, 朱述陽. 脂聯素對氣道平滑肌細胞增殖作用及一磷酸腺苷活化蛋白激酶活性的影響. 中國呼吸與危重監護雜志,2010, 9: 264 -267.
8. Silvestri M, Bontempelli M, Giacomelll M, et al. High serum levels of tumour necrosls factor-alpha and interleukin-8 in severe asthma: markers of systemic inflammation. Clin Exp Allergy, 2006, 36: 1373-1381.
9. Havel PJ. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol, 2002, 13: 51 -59.
10. Enqeli S, Feldpausch M, Gorzelniak K, et al. Association between adiponectin and mediators of inflammation in obese women.Diabetes, 2003, 52 : 942-947.
11. James A. Airway remodeling in asthma. Curr Opin Pulm Med,2005, 11: 1-6.
12. Shore SA, Terry RD, Flynt L, et al. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol, 2006, 118: 389 -395.
13. Summer R, Little FF, Ouchi N, et al. Alveolar macrophage activation and an emphysema-like phenotype in adiponectindeficient mice. Am J Physiol Lung Cell Mol Physiol, 2008, 294 :L1035-L1042.

《中國呼吸與危重監護雜志》

哮喘患者脂聯素水平的變化及意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

上一篇

下一篇

Format

Content

《中國呼吸與危重監護雜志》

哮喘患者脂聯素水平的變化及意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

上一篇

下一篇

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料