1976年Sporn等[1]提出“化學預防(chemoprevention)”的概念,指用化學藥物和飲食來干預腫瘤的發生過程,從而降低腫瘤的發生危險。化學預防對乳腺癌、結腸癌和前列腺癌等腫瘤的作用已有很多的研究,并取得了一些可喜的進展,但在肺癌領域進展甚微。1996年在《新英格蘭醫學雜志》上發表的b-胡蘿卜素聯合維生素A用于肺癌化學預防的報道[2],讓人大失所望。曾經認為β-胡蘿卜素和維生素A具有“抗癌”作用,這項研究發現用β-胡蘿卜素和維生素A長期干預肺癌高危人群,干預組患肺癌的相對風險顯著高于安慰劑對照組,相對風險為1.28(95%可信區間1.04~1.57,P=0.02),肺癌發生的風險不降反升。最新的Meta分析資料也顯示β-胡蘿卜素增加吸煙者患肺癌的風險[3]。近年來肺癌的化學預防研究一直處于“低谷”之中。
引用本文:
王長征. 吸入激素真的能夠預防肺癌嗎?. 中國呼吸與危重監護雜志, 2008, 08(3): 161-162. doi:
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Sporn MB,Dunlop NM,Newton DL,et al.Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).Fed Proc,1976,35:1332-1338.
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Omenn GS,Goodman GE,Thornquist MD,et al.Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease.N Engl J Med,1996,334:1150-1155.
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Tanvetyanon T,Bepler G.Beta-carotene in multivitamins and the possible risk of lung cancer among smokers versus former smokers:a meta-analysis and evaluation of national brands.Cancer. 2008 Apr 21 Epub ahead of print.
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Parimon T,Chien JW,Bryson CL,et al.Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2007,175:712-719.
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5. |
Khan A,Agarwal R.Lung Cancer Chemoprevention with Inhaled Corticosteroids? Am J Respir Crit Care Med,2007,176:1169.
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6. |
Buring JE,Hennekens CH.beta-carotene and cancer chemoprevention.J Cell Biochem Suppl, 1995,22:226-230.
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- 1. Sporn MB,Dunlop NM,Newton DL,et al.Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).Fed Proc,1976,35:1332-1338.
- 2. Omenn GS,Goodman GE,Thornquist MD,et al.Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease.N Engl J Med,1996,334:1150-1155.
- 3. Tanvetyanon T,Bepler G.Beta-carotene in multivitamins and the possible risk of lung cancer among smokers versus former smokers:a meta-analysis and evaluation of national brands.Cancer. 2008 Apr 21 Epub ahead of print.
- 4. Parimon T,Chien JW,Bryson CL,et al.Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2007,175:712-719.
- 5. Khan A,Agarwal R.Lung Cancer Chemoprevention with Inhaled Corticosteroids? Am J Respir Crit Care Med,2007,176:1169.
- 6. Buring JE,Hennekens CH.beta-carotene and cancer chemoprevention.J Cell Biochem Suppl, 1995,22:226-230.